Minimal model for intracellular calcium oscillations and electrical bursting in melanotrope cells of Xenopus laevis.
SourceNeural Computation, 13, 1, (2000), pp. 113--37
Article / Letter to editor
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SubjectBrain and Behaviour / Bioelectricity; Regulation of salt and water reabsorption in the renal collecting duct; Signal Transduction and Ion Transport; Hersenen en Gedrag / Bio-elektriciteit; Regulatie water en zouttransport in de verzamelbuis van de nier; Signaaltransductie en ionentransport
A minimal model is presented to explain changes in frequency, shape, and amplitude of Ca2+ oscillations in the neuroendocrine melanotrope cell of Xenopus Laevis. It describes the cell as a plasma membrane oscillator with influx of extracellular Ca2+ via voltage-gated Ca2+ channels in the plasma membrane. The Ca2+ oscillations in the Xenopus melanotrope show specific features that cannot be explained by previous models for electrically bursting cells using one set of parameters. The model assumes a KCa-channel with slow Ca2+-dependent gating kinetics that initiates and terminates the bursts. The slow kinetics of this channel cause an activation of the Kca-channel with a phase shift relative to the intracellular Ca2+ concentration. The phase shift, together with the presence of a Na+ channel that has a lower threshold than the Ca2+ channel, generate the characteristic features of the Ca2+ oscillations in the Xenopus melanotrope cell.
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