[Treatment of moderate persistent asthma: inhalation corticosteroids in combination with long acting beta 2-adrenergic agonists (bronchodilators) then with leukotriene receptor antagonists (anti-inflammatory agents); the 'step-3-dilemma']
Publication year
2003Source
Nederlands Tijdschrift voor Geneeskunde, 147, 35, (2003), pp. 1681-5ISSN
Publication type
Article / Letter to editor

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Organization
Pulmonary Diseases
Journal title
Nederlands Tijdschrift voor Geneeskunde
Volume
vol. 147
Issue
iss. 35
Page start
p. 1681
Page end
p. 5
Subject
UMCN 2.1: Heart, lung and circulationAbstract
Apart from avoiding airway-irritating agents, the most important issue in the treatment of asthma is the suppression of airway inflammation by pharmaceutical treatment. Inhaled corticosteroids are the cornerstone of the medical treatment of asthma. Recent guidelines recommend the lowest possible effective dose for asthma management. In treatment steps 2 and 3, additive therapy of low to moderately high doses of inhalation corticosteroids in combination with add-on therapy with long-acting beta 2-adrenergic agonists (LABA) and leukotriene receptor antagonists (LTRA) has proved to be effective. LABA are inhaled agents with potent bronchodilator properties, whereas LTRA are taken orally and possess mainly systemic anti-inflammatory properties.
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- Faculty of Medical Sciences [86198]
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