Publication year
2013Source
Macromolecular Bioscience, 13, 7, (2013), pp. 938-945ISSN
Publication type
Article / Letter to editor

Display more detailsDisplay less details
Organization
Pathology
Radboud Institute for Molecular Life Sciences
Former Organization
Nijmegen Centre for Molecular Life Sciences
Journal title
Macromolecular Bioscience
Volume
vol. 13
Issue
iss. 7
Page start
p. 938
Page end
p. 945
Subject
Bio-Organic Chemistry; ONCOL 3: Translational research; ONCOL 3: Translational research IGMD 9: Renal disorder; ONCOL 3: Translational research NCMLS 3: Tissue engineering and pathology; ONCOL 3: Translational research NCMLS 3: Tissue engineering and pathologyAbstract
Targeted carrier systems (e.g., liposomes or nanoparticles) are used to specifically deliver drugs to a site of interest. Site-direction can be achieved by attachment of targeting molecules, such as peptides, DNA/RNA, or antibodies, to the surface of the carrier. Here, the formation of polymersomes with tumor-targeting potential is described. A single-domain antibody (A12) that specifically targets PlexinD1 (a transmembrane protein overexpressed in tumor vasculature) is equipped with an azide-functionality using expressed protein ligation. This azide-containing A12 can subsequently be attached to BCN-functionalized polymersomes using a strain-promoted azide alkyne cycloaddition, thereby forming polymersomes with tumor-targeting potential.
This item appears in the following Collection(s)
- Academic publications [204968]
- Faculty of Medical Sciences [81049]
- Faculty of Science [32332]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.