Nanobody-functionalized polymersomes for tumor-vessel targeting

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Title:	Nanobody-functionalized polymersomes for tumor-vessel targeting
Author(s):	Debets, M.F.; Leenders, W.P.J. ; Verrijp, K. ; Zonjee, M.; Meeuwissen, S.A.; Otte-Holler, I. ; Hest, J.C.M. van
Publication year:	2013
Source:	Macromolecular Bioscience, vol. 13, iss. 7, (2013), pp. 938-945
ISSN:	1616-5187
DOI:	http://dx.doi.org/10.1002/mabi.201300039
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/123085
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Subject:	Bio-Organic Chemistry ONCOL 3: Translational research ONCOL 3: Translational research IGMD 9: Renal disorder ONCOL 3: Translational research NCMLS 3: Tissue engineering and pathology ONCOL 3: Translational research NCMLS 3: Tissue engineering and pathology
Organization:	Pathology Radboud Institute for Molecular Life Sciences
Former Organization:	Nijmegen Centre for Molecular Life Sciences
Journal title:	Macromolecular Bioscience
Volume:	vol. 13
Issue:	iss. 7
Page start:	p. 938
Page end:	p. 945
Abstract:	Targeted carrier systems (e.g., liposomes or nanoparticles) are used to specifically deliver drugs to a site of interest. Site-direction can be achieved by attachment of targeting molecules, such as peptides, DNA/RNA, or antibodies, to the surface of the carrier. Here, the formation of polymersomes with tumor-targeting potential is described. A single-domain antibody (A12) that specifically targets PlexinD1 (a transmembrane protein overexpressed in tumor vasculature) is equipped with an azide-functionality using expressed protein ligation. This azide-containing A12 can subsequently be attached to BCN-functionalized polymersomes using a strain-promoted azide alkyne cycloaddition, thereby forming polymersomes with tumor-targeting potential.