Nanobody-functionalized polymersomes for tumor-vessel targeting
SourceMacromolecular Bioscience, 13, 7, (2013), pp. 938-945
Article / Letter to editor
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Radboud Institute for Molecular Life Sciences
Nijmegen Centre for Molecular Life Sciences
SubjectBio-Organic Chemistry; ONCOL 3: Translational research; ONCOL 3: Translational research IGMD 9: Renal disorder; ONCOL 3: Translational research NCMLS 3: Tissue engineering and pathology; ONCOL 3: Translational research NCMLS 3: Tissue engineering and pathology
Targeted carrier systems (e.g., liposomes or nanoparticles) are used to specifically deliver drugs to a site of interest. Site-direction can be achieved by attachment of targeting molecules, such as peptides, DNA/RNA, or antibodies, to the surface of the carrier. Here, the formation of polymersomes with tumor-targeting potential is described. A single-domain antibody (A12) that specifically targets PlexinD1 (a transmembrane protein overexpressed in tumor vasculature) is equipped with an azide-functionality using expressed protein ligation. This azide-containing A12 can subsequently be attached to BCN-functionalized polymersomes using a strain-promoted azide alkyne cycloaddition, thereby forming polymersomes with tumor-targeting potential.
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