Publication year
2001Source
Neurology, 56, 12, (2001), pp. 1766-8ISSN
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Publication type
Article / Letter to editor

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Organization
Neurology
Journal title
Neurology
Volume
vol. 56
Issue
iss. 12
Page start
p. 1766
Page end
p. 8
Subject
Neuromuscular and neurometabolic disorders; Tumor pathology; Neuromusculaire en neurometabole aandoeningen; Tumor pathologieAbstract
The authors report a patient with neurofibromatosis type 2 (NF2) presenting with an axonal mononeuropathy multiplex. Sural nerve biopsy showed small scattered groups of Schwann cells transformed into irregular branching cells with abnormal cell-cell contacts. The authors hypothesize that defective Schwann cell function, due to inactivation of the NF2 gene product merlin, leads to changes in morphology, cell-cell contact, and growth, and finally to degeneration of axons.
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- Academic publications [227436]
- Faculty of Medical Sciences [86157]
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