Predictors of relapse after discontinuation of long-term benzodiazepine use by minimal intervention: a 2-year follow-up study.
SourceFamily Practice, 20, 4, (2003), pp. 370-2
Article / Letter to editor
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Epidemiology, Biostatistics & HTA
SubjectEBP 1: Determinants in Health and Disease; EBP 3: Effective Primary Care and Public Health; UMCN 3.2: Cognitive neurosciences
BACKGROUND: Long-term results of minimal intervention strategies to cut down benzodiazepine use are not available. OBJECTIVE: To evaluate the relapse rate over a two-year period and to search for predictors of relapse among patients who quit benzodiazepine use after receiving a discontinuation letter. METHODS: Baseline assessment and prospective monitoring of the medical records of 109 patients who quit long-term benzodiazepine use after a minimal intervention strategy in general practice. RESULTS: After 819 +/- 100 days of follow-up, 53 (49%) patients had remained completely abstinent. Two independent predictors of relapse were identified by Cox regression analysis: use of more than 10 mg diazepam equivalent (RR = 2.4 [1.2 - 4.7]) and poor general health perception (RR = 0.98 [0.97 - 0.99]). CONCLUSION: Short-term success rates after a minimal intervention were maintained well during long-term follow-up. High-dose users have the highest risk of relapse.
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- Faculty of Medical Sciences 
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