Altered resting state EEG in chronic pancreatitis patients: Toward a marker for chronic pain
Publication year
2013Author(s)
Number of pages
10 p.
Source
Journal of Pain Research, 6, 6, (2013), pp. 815-824ISSN
Publication type
Article / Letter to editor

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Organization
SW OZ DCC SMN
SW OW PsKI [owi]
Journal title
Journal of Pain Research
Volume
vol. 6
Issue
iss. 6
Languages used
English (eng)
Page start
p. 815
Page end
p. 824
Subject
Biological psychology; DI-BCB_DCC_Theme 3: Plasticity and Memory; Learning and Plasticity; Biologische psychologieAbstract
Objectives: Electroencephalography (EEG) may be a promising source of physiological biomarkers accompanying chronic pain. Several studies in patients with chronic neuropathic pain have reported alterations in central pain processing, manifested as slowed EEG rhythmicity and increased EEG power in the brain's resting state. We aimed to investigate novel potential markers of chronic pain in the resting state EEG of patients with chronic pancreatitis.
Participants: Resting state EEG data from 16 patients with persistent abdominal pain due to chronic pancreatitis (CP) were compared to data from healthy controls matched for age, sex and education.
Methods: The peak alpha frequency (PAF) and power amplitude in the alpha band (7.5–13 Hz) were compared between groups in four regions of interest (frontal, central, parietal, and occipital) and were correlated with pain duration.
Results: The average PAF was lowered in CP patients compared with that in healthy controls, observed as a statistically significant between-group effect (mean 9.9 versus 9.5 Hz; P=0.049). Exploratory post hoc analysis of average PAF per region of interest revealed a significant difference, particularly in the parietal and occipital regions. In addition, we observed a significant correlation between pain duration and PAF and showed increased shifts in PAF with longer pain durations. No significant group differences were found in peak power amplitudes.
Conclusion: CP pain is associated with alterations in spontaneous brain activity, observed as a shift toward lower PAF. This shift correlates with the duration of pain, which demonstrates that PAF has the potential to be a clinically feasible biomarker for chronic pain. These findings could be helpful for assisting diagnosis, establishing optimal treatment, and studying efficacy of new therapeutic agents in chronic pain patients.
This item appears in the following Collection(s)
- Academic publications [203856]
- Electronic publications [102283]
- Faculty of Social Sciences [27309]
- Open Access publications [70939]
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