Vascular endothelial growth factor-A(165) induces progression of melanoma brain metastases without induction of sprouting angiogenesis.

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Title:	Vascular endothelial growth factor-A(165) induces progression of melanoma brain metastases without induction of sprouting angiogenesis.
Author(s):	Kusters, B. ; Leenders, W.P.J. ; Wesseling, P. ; Smits, D.; Verrijp, K. ; Ruiter, D.J. ; Peters, J.P.W. ; Kogel, A.J. van der ; Waal, R.M.W. de
Publication year:	2002
Source:	Cancer Research, vol. 62, iss. 2, (2002), pp. 341-345
ISSN:	0008-5472
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/121089
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Subject:	Experimental radiotherapy and neuro-oncology. Tumor pathology Experimentele radiotherapie en neuro-oncologie. Tumor pathologie
Organization:	Pathology Radiation Oncology
Journal title:	Cancer Research
Volume:	vol. 62
Issue:	iss. 2
Page start:	p. 341
Page end:	p. 345
Abstract:	We investigated the mechanisms of vascularization in a brain metastases model of malignant melanoma. Parenchymal metastases expressing little vascular endothelial growth factor-A (VEGF-A) co-opted the preexistent brain vasculature, leading to an infiltrative phenotype. Metastases of the human melanoma cell line Mel57, engineered to express recombinant VEGF-A(165), showed accelerated growth in a combined expansive and infiltrative pattern with marked central necrosis. This difference in growth profile was accompanied by dilation of co-opted intra- and peritumoral vessels with concomitant induction of vascular permeability. Our data show that modulation of preexistent vasculature can contribute to malignant progression without induction of sprouting angiogenesis.