Activity of posaconazole in treatment of experimental disseminated zygomycosis.

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Title:	Activity of posaconazole in treatment of experimental disseminated zygomycosis.
Author(s):	Danaoui, E.; Meis, J.F.G.M. ; Loebenberg, D.; Verweij, P.E.
Publication year:	2003
Source:	Antimicrobial Agents and Chemotherapy, vol. 47, iss. 11, (2003), pp. 3647-3650
ISSN:	0066-4804
DOI:	https://doi.org/10.1128/AAC.47.11.3647-3650.2003
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/121009
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Subject:	UMCN 4.1: Microbial pathogenesis and host defense
Organization:	Medical Microbiology
Journal title:	Antimicrobial Agents and Chemotherapy
Volume:	vol. 47
Issue:	iss. 11
Page start:	p. 3647
Page end:	p. 3650
Abstract:	Three isolates of zygomycetes were used to produce a disseminated infection in nonimmunocompromised mice. Against all zygomycete strains, amphotericin B significantly prolonged survival. Itraconazole was inactive against Rhizopus microsporus and Rhizopus oryzae but was partially active against Absidia corymbifera. Posaconazole had no beneficial effects against R. oryzae but showed partial activity against A. corymbifera. Posaconazole had a clear dose-response effect against R. microsporus.