Invasive aspergillosis in two patients with Pearson syndrome.
SourcePediatric Infectious Disease Journal, 18, 8, (1999), pp. 739-741
Article / Letter to editor
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Paediatrics - OUD tm 2017
Pediatric Infectious Disease Journal
SubjectPathogenesis, epidemiology, and treatment of microbial infections; Pathogenese, epidemiologie en behandeling van microbiële infecties
Invasive aspergillosis is a serious opportunistic infection in the immunocompromised host. In the pediatric population invasive aspergillosis is seen predominantly in patients with hematologic malignancie, chronic granullamotous disease (CGD) and AIDS. Invasive aspergillosis carries a high case fatality rate even with optimal antifungal therapy. Neutropenia for a prolonged period of time is the key risk factor for developing invasive aspergillosis. Premature neonates admitted to the neonatal intensive care unit are at risk too, because of their immature phagocytic capacity and the frequent use of corticosteroids.
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