DAZLA: an important candidate gene in male subfertility?

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Title:	DAZLA: an important candidate gene in male subfertility?
Author(s):	Golde, R.J.T. van ; Tuerlings, J.H.A.M. ; Kremer, J.A.M. ; Braat, D.D.M. ; Schoute, F.; Hoefsloot, L.H.
Publication year:	2001
Source:	Journal of Assisted Reproduction and Genetics, vol. 18, iss. 7, (2001), pp. 395--9
ISSN:	1058-0468
DOI:	https://doi.org/10.1023/A:1016678624225
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/120721
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Subject:	Elucidation of hereditary disorders and their molecular diagnosis Prevention of disorders in human reproduction: (Patho)Physiological, endocrinological and methabolic aspects Opheldering van erfelijke ziekten en hun moleculaire diagnostiek Preventie van stoornissen in de menselijke voortplanting: (Patho-)fysiologische, endocriene en metabole aspecten.
Organization:	Gynaecology Human Genetics
Journal title:	Journal of Assisted Reproduction and Genetics
Volume:	vol. 18
Issue:	iss. 7
Page start:	p. 395-
Page end:	p. 9
Abstract:	PURPOSE: To study the role of the autosomal candidate gene DAZLA (Deleted in AZoospermia Like Autosome) in male subfertility. METHODS: We reviewed clinical data of subfertile men with oligozoospermia or azoospermia, mostly candidates for intracytoplasmic sperm injection (ICSI). Mutation detection was performed using polymerase chain reaction followed by single strand conformation polymorphism analysis. All shifted bands were analyzed by sequencing. RESULTS: We searched for mutations in 44 subfertile men. Nine subfertile men were included, because family history showed that their brothers also faced fertility problems. In these men a possible autosomal gene defect may contribute to their fertility problem. No mutations were found, except for two polymorphisms in intron 4 and 5. CONCLUSION: At this moment it does not seem relevant to search for possible mutations in the DAZLA gene in clinical practice.