In vitro susceptibilities of zygomycetes to combinations of antimicrobial agents.
SourceAntimicrobial Agents and Chemotherapy, 46, 8, (2002), pp. 2708-2711
Article / Letter to editor
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Antimicrobial Agents and Chemotherapy
SubjectPathogenesis, epidemiology, and treatment of microbial infections; Pathogenese, epidemiologie en behandeling van microbiële infecties
Combinations of antimicrobial agents were tested against 35 strains of zygomycetes. The interaction between amphotericin B and rifampin was synergistic or additive. Flucytosine alone was inactive and, upon combination with amphotericin B, synergy was not achieved. The combination of amphotericin B with terbinafine was synergistic for 20% of strains, and the interaction between terbinafine and voriconazole was synergistic for 44% of strains. Antagonism was not observed.
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