Publication year
2001Source
Critical Reviews in Therapeutic Drug Carrier Systems, 18, 6, (2001), pp. 551--66ISSN
Publication type
Article / Letter to editor

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Organization
Nuclear Medicine
Radboudumc Extern
Journal title
Critical Reviews in Therapeutic Drug Carrier Systems
Volume
vol. 18
Issue
iss. 6
Page start
p. 551-
Page end
p. 66
Subject
Development of radiopharmaceuticals for diagnosis and therapy of pathological processes.; Ontwikkeling van radiofarmaca ten behoeve van diagnose en behandeling van ziekteprocessen.Abstract
Recent studies with PEG liposomes in patients have consistently shown that liposomes can induce side effects (flushing, tightness of the chest). Furthermore, the blood clearance of PEG liposomes was shown to be dose-dependent: at lipid doses lower than 1 micromol/kg, PEG liposomes do not show the long-circulation property but instead are cleared relatively rapidly from the bloodstream. Another remarkable observation was that repeated injections of PEG liposomes led to significant pharmacokinetic changes: the circulatory half-life of a second dose of radiolabeled PEG liposomes dramatically decreased when given from 5 days to up to 4 weeks after a first injection. In these three unexpected phenomena, proteins of the complement system seem to play a key role. Therefore, one has to consider that PEG liposomes are not inert drug-carrying vehicles in vivo. Pharmacological effects can occur, induced solely by using liposomal particles irrespective of the drug content.
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- Faculty of Medical Sciences [80231]
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