TY  - JOUR
AU  - Helmich, R.C.G.
AU  - Derikx, L.C.E.M.
AU  - Bakker, M.
AU  - Scheeringa, R.
AU  - Bloem, B.R.
AU  - Toni, I.
PY  - 2010
UR  - https://hdl.handle.net/2066/89191
AB  - Parkinson's disease (PD) is characterized by striatal dopamine depletion, especially in the posterior putamen. The dense connectivity profile of the striatum suggests that these local impairments may propagate throughout the whole cortico-striatal network. Here we test the effect of striatal dopamine depletion on cortico-striatal network properties by comparing the functional connectivity profile of the posterior putamen, the anterior putamen, and the caudate nucleus between 41 PD patients and 36 matched controls. We used multiple regression analyses of resting-state functional magnetic resonance imaging data to quantify functional connectivity across different networks. Each region had a distinct connectivity profile that was similarly expressed in patients and controls: the posterior putamen was uniquely coupled to cortical motor areas, the anterior putamen to the pre-supplementary motor area and anterior cingulate cortex, and the caudate nucleus to the dorsal prefrontal cortex. Differences between groups were specific to the putamen: although PD patients showed decreased coupling between the posterior putamen and the inferior parietal cortex, this region showed increased functional connectivity with the anterior putamen. We conclude that dopamine depletion in PD leads to a remapping of cerebral connectivity that reduces the spatial segregation between different cortico-striatal loops. These alterations of network properties may underlie abnormal sensorimotor integration in PD.
TI  - Spatial remapping of cortico-striatal connectivity in Parkinson's disease.
EP  - 1186
SN  - 1047-3211
IS  - iss. 5
SP  - 1175
JF  - Cerebral Cortex
VL  - vol. 20
N1  - 1 mei 2010
DO  - https://doi.org/10.1093/cercor/bhp178
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/89191/89191.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - Werf, J. van der
AU  - Jensen, O.
AU  - Fries, P.
AU  - Medendorp, W.P.
PY  - 2010
UR  - https://hdl.handle.net/2066/84272
TI  - Neuronal Synchronization in Human Posterior Parietal Cortex during Reach Planning
EP  - 1412
SN  - 0270-6474
IS  - iss. 4
SP  - 1402
JF  - The Journal of Neuroscience
VL  - vol. 30
DO  - https://doi.org/10.1523/JNEUROSCI.3448-09.2010
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/84272/84272.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - Mazaheri, A.
AU  - Jensen, O.
PY  - 2010
UR  - https://hdl.handle.net/2066/115477
TI  - Rhythmic Pulsing: Linking ongoing brain activity with evoked responses
EP  - 13
SN  - 1662-5161
SP  - 1
JF  - Frontiers in Human Neuroscience
VL  - vol. 4
DO  - https://doi.org/10.3389/fnhum.2010.00177
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/115477/115477.pdf?sequence=1
ER  - 
TY  - JOUR
AU  - Jensen, O.
AU  - Mazaheri, A.
PY  - 2010
UR  - https://hdl.handle.net/2066/115479
TI  - Shaping functional architecture by oscillatory alpha activity: gating by inhibition
EP  - 8
SN  - 1662-5161
SP  - 1
JF  - Frontiers in Human Neuroscience
VL  - vol. 4
DO  - https://doi.org/10.3389/fnhum.2010.00186
L1  - https://repository.ubn.ru.nl/bitstream/handle/2066/115479/115479.pdf?sequence=1
ER  -