TY - JOUR AU - Werf, J. van der AU - Jensen, O. AU - Fries, P. AU - Medendorp, W.P. PY - 2010 UR - https://hdl.handle.net/2066/90662 AB - Although single-unit studies in monkeys have identified effector-related regions in the posterior parietal cortex (PPC) during saccade and reach planning, the degree of effector specificity of corresponding human regions, as established by recordings of the blood oxygen level-dependent signal, is still under debate. Here, we addressed this issue from a different perspective, by studying the neuronal synchronization of the human PPC during both reach and saccade planning. Using magnetoencephalography (MEG), we recorded ongoing brain activity while subjects performed randomly alternating trials of memory-guided reaches or saccades. Additionally, subjects performed a dissociation task requiring them to plan both a memory-guided saccade and reach to locations in opposing visual hemifields. Weexamined changes in spectral power of the MEG signal during a 1.5 smemory period in relation to target location (left/right) and effector type (eye/hand). The results show direction-selective synchronization in the 70-90 Hz gamma frequency band, originating from the medial aspect of the PPC, when planning a reaching movement. In contrast, activity in a more central portion of the PPC was synchronized in a lower gamma band (50-60 Hz) when planning the direction of a saccade. Both observations were corroborated in the dissociation task. In the lower frequency bands, we observed sustained alpha-band (8-12 Hz) desynchronization in occipitoparietal regions, but in an effector-unspecific manner. These results suggest that distinct modules in the posterior parietal cortex encode movement goals of different effectors by selective gamma-band activity, compatible with the functional organization of monkey PPC. TI - Neuronal Synchronization in Human Posterior Parietal Cortex during Reach Planning EP - 1412 SN - 0270-6474 IS - iss. 4 SP - 1402 JF - The Journal of Neuroscience VL - vol. 30 DO - http://dx.doi.org/10.1523/JNEUROSCI.3448-09.2010 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/90662/90662.pdf?sequence=1 ER - TY - JOUR AU - Stelzel, C. AU - Basten, U. AU - Montag, C. AU - Reuter, M. AU - Fiebach, C.J. PY - 2010 UR - https://hdl.handle.net/2066/90400 AB - Recent studies suggest an association of dopamine D2 receptor (DRD2) availability with flexibility in reward-based learning. We extend these results by demonstrating an association of genetically based differences in DRD2 density with the ability to intentionally switch between nonrewarded tasks: noncarriers of the A1 allele of the DRD2/ANKK1-TaqIa polymorphism, associated with higher DRD2 density, show increased task-switching costs, increased prefrontal switching activity in the inferior frontal junction area, and increased functional connectivity in dorsal frontostriatal circuits, relative to A1 allele carriers. A DRD2 haplotype analysis in the same sample confirmed these results, indicating an association between high D2 density and increased task-switching effort. Our results provide evidence that converges with that from association studies relating increased D2 density to deficits in cognitive flexibility in schizophrenia. We suggest that individual differences in striatal D2 signaling in healthy humans modulate goal-directed gating to prefrontal cortex, thus leading to individual differences in switching intentionally to newly relevant behaviors. TI - Frontostriatal Involvement in Task Switching Depends on Genetic Differences in D2 Receptor Density EP - 14212 SN - 0270-6474 IS - iss. 42 SP - 14205 JF - The Journal of Neuroscience VL - vol. 30 DO - http://dx.doi.org/10.1523/JNEUROSCI.1062-10.2010 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/90400/90400.pdf?sequence=1 ER - TY - JOUR AU - Russell, G.M. AU - Henley, D.E. AU - Leendertz, J. AU - Douthwaite, J.A. AU - Wood, S.A. AU - Stevens, A. AU - Woltersdorf, W.W. AU - Peeters, B.W.M.M. AU - Ruigt, G.S.F. AU - White, A. AU - Veldhuis, J.D. AU - Lightman, S.L. PY - 2010 UR - https://hdl.handle.net/2066/84121 TI - Rapid Glucocorticoid Receptor-Mediated Inhibition of Hypothalamic-Pituitary-Adrenal Ultradian Activity in Healthy Males EP - 6115 SN - 0270-6474 IS - iss. 17 SP - 6106 JF - The Journal of Neuroscience VL - vol. 30 PS - 10 p. DO - https://doi.org/10.1523/JNEUROSCI.5332-09.2010 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/84121/84121.pdf?sequence=1 ER - TY - JOUR AU - Bremen, P. AU - Wanrooij, M.M. van AU - Opstal, A.J. van PY - 2010 UR - https://hdl.handle.net/2066/84228 TI - Pinna cues determine orienting response modes to synchronous sounds in elevation EP - 204 SN - 0270-6474 IS - iss. 1 SP - 194 JF - The Journal of Neuroscience VL - vol. 30 PS - 11 p. DO - https://doi.org/10.1523/JNEUROSCI.2982-09.2010 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/84228/84228.pdf?sequence=1 ER - TY - JOUR AU - van Kesteren, M.T. AU - Rijpkema, M.J.P. AU - Ruiter, D.J. AU - Fernandez, G.S.E. PY - 2010 UR - https://hdl.handle.net/2066/89375 TI - Retrieval of associative information congruent with prior knowledge is related to increased medial prefrontal activity and connectivity. EP - 15894 SN - 0270-6474 IS - iss. 47 SP - 15888 JF - The Journal of Neuroscience VL - vol. 30 DO - https://doi.org/10.1523/JNEUROSCI.2674-10.2010 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/89375/89375.pdf?sequence=1 ER - TY - JOUR AU - Kesteren, M.T.R. van AU - Rijpkema, M.J.P. AU - Ruiter, D.J. AU - Fernandez, G.S.E. PY - 2010 UR - https://hdl.handle.net/2066/89374 AB - We remember information that is congruent instead of incongruent with prior knowledge better, but the underlying neural mechanisms related to this enhancement are still relatively unknown. Recently, this memory enhancement due to a prior schema has been suggested to be based on rapid neocortical assimilation of new information, related to optimized encoding and consolidation processes. The medial prefrontal cortex (mPFC) is thought to be important in mediating this process, but its role in retrieval of schema-consistent information is still unclear. In this study, we regarded multisensory congruency with prior knowledge as a schema and used this factor to probe retrieval of consolidated memories either consistent or inconsistent with prior knowledge. We conducted a visuotactile learning paradigm in which participants studied visual motifs randomly associated with word-fabric combinations that were either congruent or incongruent with common knowledge. The next day, participants were scanned using functional magnetic resonance imaging while their memory was tested. Congruent associations were remembered better than incongruent ones. This behavioral finding was parallelized by stronger retrieval-related activity in and connectivity between medial prefrontal and left somatosensory cortex. Moreover, we found a positive across-subject correlation between the connectivity enhancement and the behavioral congruency effect. These results show that successful retrieval of congruent compared to incongruent visuotactile associations is related to enhanced processing in an mPFC-somatosensory network, and support the hypothesis that new information that fits a preexisting schema is more rapidly assimilated in neocortical networks, a process that may be mediated, at least in part, by the mPFC. TI - Retrieval of associative information congruent with prior knowledge is related to increased medial prefrontal activity and connectivity. EP - 15894 SN - 0270-6474 IS - iss. 47 SP - 15888 JF - The Journal of Neuroscience VL - vol. 30 DO - https://doi.org/10.1523/JNEUROSCI.2674-10.2010 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/89374/89374.pdf?sequence=1 ER - TY - JOUR AU - de Lange, F.P. AU - Jensen, O. AU - Dehaene, S. PY - 2010 UR - https://hdl.handle.net/2066/115465 AB - In the last decade, great progress has been made in characterizing the accumulation of neural information during simple unitary perceptual decisions. However, much less is known about how sequentially presented evidence is integrated over time for successful decision making. The aim of this study was to study the mechanisms of sequential decision making in humans. In a magnetoencephalography (MEG) study, we presented healthy volunteers with sequences of centrally presented arrows. Sequence length varied between one and five arrows, and the accumulated directions of the arrows informed the subject about which hand to use for a button press at the end of the sequence (e.g., LRLRR should result in a right-hand press). Mathematical modeling suggested that nonlinear accumulation was the rational strategy for performing this task in the presence of no or little noise, whereas quasilinear accumulation was optimal in the presence of substantial noise. MEG recordings showed a correlate of evidence integration over parietal and central cortex that was inversely related to the amount of accumulated evidence (i.e., when more evidence was accumulated, neural activity for new stimuli was attenuated). This modulation of activity likely reflects a top–down influence on sensory processing, effectively constraining the influence of sensory information on the decision variable over time. The results indicate that, when making decisions on the basis of sequential information, the human nervous system integrates evidence in a nonlinear manner, using the amount of previously accumulated information to constrain the accumulation of additional evidence. TI - Accumulation of evidence during sequential decision making: the importance of top-down factors EP - 738 SN - 0270-6474 SP - 731 JF - The Journal of Neuroscience VL - vol. 30 DO - https://doi.org/10.1523/JNEUROSCI.4080-09.2010 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/115465/115465-OA.pdf?sequence=1 ER - TY - JOUR AU - Werf, J. van der AU - Jensen, O. AU - Fries, P. AU - Medendorp, W.P. PY - 2010 UR - https://hdl.handle.net/2066/84274 AB - Although single-unit studies in monkeys have identified effector-related regions in the posterior parietal cortex (PPC) during saccade and reach planning, the degree of effector specificity of corresponding human regions, as established by recordings of the blood oxygen level-dependent signal, is still under debate. Here, we addressed this issue from a different perspective, by studying the neuronal synchronization of the human PPC during both reach and saccade planning. Using magnetoencephalography (MEG), we recorded ongoing brain activity while subjects performed randomly alternating trials of memory-guided reaches or saccades. Additionally, subjects performed a dissociation task requiring them to plan both a memory-guided saccade and reach to locations in opposing visual hemifields. We examined changes in spectral power of the MEG signal during a 1.5 s memory period in relation to target location (left/right) and effector type (eye/hand). The results show direction-selective synchronization in the 70-90 Hz gamma frequency band, originating from the medial aspect of the PPC, when planning a reaching movement. In contrast, activity in a more central portion of the PPC was synchronized in a lower gamma band (50-60 Hz) when planning the direction of a saccade. Both observations were corroborated in the dissociation task. In the lower frequency bands, we observed sustained alpha-band (8-12 Hz) desynchronization in occipitoparietal regions, but in an effector-unspecific manner. These results suggest that distinct modules in the posterior parietal cortex encode movement goals of different effectors by selective gamma-band activity, compatible with the functional organization of monkey PPC. TI - Neuronal synchronization in human posterior parietal cortex during reach planning EP - 1412 SN - 0270-6474 IS - iss. 4 SP - 1402 JF - The Journal of Neuroscience VL - vol. 30 PS - 11 p. DO - https://doi.org/10.1523/JNEUROSCI.3448-09.2010 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/84274/84274.pdf?sequence=1 ER - TY - JOUR AU - Scheibe, C. AU - Ullsperger, M. AU - Sommer, W. AU - Heekeren, H.R. PY - 2010 UR - https://hdl.handle.net/2066/90265 AB - Prior knowledge of the probabilities concerning decision alternatives facilitates the selection of more likely alternatives to the disadvantage of others. The neural basis of prior probability (PP) integration into the decision-making process and associated preparatory processes is, however, still essentially unknown. Furthermore, trial-to-trial fluctuations in PP processing have not been considered thus far. In a previous study, we found that the amplitude of the contingent negative variation (CNV) in a precueing task is sensitive to PP information (Scheibe et al., 2009). We investigated brain regions with a parametric relationship between neural activity and PP and those regions involved in PP processing on a trial-to-trial basis in simultaneously recorded electroencephalographic (EEG) and functional magnetic resonance imaging (fMRI) data. Conventional fMRI analysis focusing on the information content of the probability precue revealed increasing activation of the posterior medial frontal cortex with increasing PP, supporting its putative role in updating action values. EEG-informed fMRI analysis relating single-trial CNV amplitudes to the hemodynamic signal addressed trial-to-trial fluctuations in PP processing. We identified a set of regions mainly consisting of frontal, parietal, and striatal regions that represents unspecific response preparation on a trial-to-trial basis. A subset of these regions, namely, the dorsolateral prefrontal cortex, the inferior frontal gyrus, and the inferior parietal lobule, showed activations that exclusively represented the contributions of PP to the trial-to-trial fluctuations of the CNV. TI - Effects of Parametrical and Trial-to-Trial Variation in Prior Probability Processing Revealed by Simultaneous Electroencephalogram/Functional Magnetic Resonance Imaging EP - 16717 SN - 0270-6474 IS - iss. 49 SP - 16709 JF - The Journal of Neuroscience VL - vol. 30 DO - https://doi.org/10.1523/JNEUROSCI.3949-09.2010 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/90265/90265.pdf?sequence=1 ER - TY - JOUR AU - King, J.A. AU - Korb, F.M. AU - Cramon, D.Y. von AU - Ullsperger, M. PY - 2010 UR - https://hdl.handle.net/2066/90763 AB - Error monitoring by the posterior medial frontal cortex (pMFC) has been linked to post-error behavioral adaptation effects and cognitive control dynamics in lateral prefrontal cortex (LPFC). It remains unknown, however, whether control adjustments following errors produce post-error behavioral adjustments (PEBAs) by inhibiting inappropriate responses or facilitating goal-directed ones. Here we used functional magnetic resonance imaging to investigate the hemodynamic correlates of PEBAs in a stimulus–response compatibility task. Our task was designed to test whether PEBAs are implemented by suppressing motor responses primed by irrelevant stimulus features (face location), redirecting attention to relevant features (face gender), or both or neither of these possibilities. Independent of PEBAs, error-related pMFC activation was followed by post-error recruitment of prefrontal and parietal control regions and, crucially, both (1) suppressed response-related activity in sensorimotor cortex and (2) enhanced target processing in face-sensitive sensory cortex ("fusiform face area"). More importantly, by investigating the covariation between post-error hemodynamic activity and individual differences in PEBAs, we showed that modulation of task-related motor and sensory processing was dependent on whether participants produced generally slower responses ("post-error slowing"; PES) or selectively reduced interference effects ("post-error reduction of interference"; PERI), respectively. Each of these behaviorally dependent effects was mediated by distinct LPFC control mechanisms (PES: inferior frontal junction; PERI: superior frontal sulcus). While establishing relationships between PEBAs and cognitive control, our findings suggest that the neural architecture underlying sequential behavioral adaptation may be determined primarily by how control is executed by the individual when adjustments are needed. TI - Post-Error Behavioral Adjustments Are Facilitated by Activation and Suppression of Task-Relevant and Task-Irrelevant Information Processing EP - 12770 SN - 0270-6474 IS - iss. 38 SP - 12759 JF - The Journal of Neuroscience VL - vol. 30 DO - https://doi.org/10.1523/JNEUROSCI.3274-10.2010 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/90763/90763.pdf?sequence=1 ER - TY - JOUR AU - Henckens, M.J.A.G. AU - Wingen, G.A. van AU - Joëls, M. AU - Fernandez, G.S.E. PY - 2010 UR - https://hdl.handle.net/2066/87666 TI - Time-dependent effects of corticosteroids on human amygdala processing EP - 12732 SN - 0270-6474 IS - iss. 38 SP - 12725 JF - The Journal of Neuroscience VL - vol. 30 DO - https://doi.org/10.1523/JNEUROSCI.3112-10.2010 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/87666/87666.pdf?sequence=1 ER - TY - JOUR AU - Henckens, M.J.A.G. AU - Wingen, G.A. van AU - Joëls, M. AU - Fernandez, G.S.E. PY - 2010 UR - https://hdl.handle.net/2066/87667 AB - Acute stress is associated with a sensitized amygdala. Corticosteroids, released in response to stress, are suggested to restore homeostasis by normalizing/desensitizing brain processing in the aftermath of stress. Here, we investigated the effects of corticosteroids on amygdala processing using functional magnetic resonance imaging. Since corticosteroids exert rapid nongenomic and slow genomic effects, we administered hydrocortisone either 75 min (rapid effects) or 285 min (slow effects) before scanning in a randomized, double-blind, placebo-controlled design. Seventy-two healthy males were scanned while viewing faces morphing from a neutral facial expression into fearful or happy expressions. Imaging results revealed that hydrocortisone desensitizes amygdala responsivity rapidly, while it selectively normalizes responses to negative stimuli slowly. Psychophysiological interaction analyses suggested that this slow normalization is related to an altered coupling of the amygdala with the medial prefrontal cortex. These results reveal a temporarily fine-tuned mechanism that is critical for avoiding amygdala overshoot during stress and enabling adequate recovery thereafter. TI - Time-dependent effects of corticosteroids on human amygdala processing. EP - 12732 SN - 0270-6474 IS - iss. 38 SP - 12725 JF - The Journal of Neuroscience VL - vol. 30 DO - https://doi.org/10.1523/JNEUROSCI.3112-10.2010 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/87667/87667.pdf?sequence=1 ER - TY - JOUR AU - Vinck, M. AU - Lima, B. AU - Womelsdorf, T. AU - Oostenveld, R. AU - Singer, W. AU - Neuenschwander, S. AU - Fries, P. PY - 2010 UR - https://hdl.handle.net/2066/83334 TI - Gamma-phase shifting in awake monkey visual cortex EP - 1257 SN - 0270-6474 IS - iss. 4 SP - 1250 JF - The Journal of Neuroscience VL - vol. 30 PS - 8 p. DO - https://doi.org/10.1523/JNEUROSCI.1623-09.2010 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/83334/83334.pdf?sequence=1 ER - TY - JOUR AU - Vinck, M. AU - Lima, B. AU - Womelsdorf, T. AU - Oostenveld, R. AU - Singer, W. AU - Neuenschwander, S. AU - Fries, P. PY - 2010 UR - https://hdl.handle.net/2066/83330 AB - Gamma-band synchronization is abundant in nervous systems. Typically, the strength or precision of gamma-band synchronization is studied. However, the precise phase with which individual neurons are synchronized to the gamma-band rhythm might have interesting consequences for their impact on further processing and for spike timing-dependent plasticity. Therefore, we investigated whether the spike times of individual neurons shift systematically in the gamma cycle as a function of the neuronal activation strength. We found that stronger neuronal activation leads to spikes earlier in the gamma cycle, i.e., we observed gamma-phase shifting. Gamma-phase shifting occurred on very rapid timescales. It was particularly pronounced for periods in which gamma-band synchronization was relatively weak and for neurons that were only weakly coupled to the gamma rhythm. We suggest that gamma-phase shifting is brought about by an interplay between overall excitation and gamma-rhythmic synaptic input and has interesting consequences for neuronal coding, competition, and plasticity. TI - Gamma-phase shifting in awake monkey visual cortex EP - 1257 SN - 0270-6474 IS - iss. 4 SP - 1250 JF - The Journal of Neuroscience VL - vol. 30 PS - 8 p. DO - https://doi.org/10.1523/JNEUROSCI.1623-09.2010 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/83330/83330.pdf?sequence=1 ER - TY - JOUR AU - Werf, J. van der AU - Jensen, O. AU - Fries, P. AU - Medendorp, W.P. PY - 2010 UR - https://hdl.handle.net/2066/84272 TI - Neuronal Synchronization in Human Posterior Parietal Cortex during Reach Planning EP - 1412 SN - 0270-6474 IS - iss. 4 SP - 1402 JF - The Journal of Neuroscience VL - vol. 30 DO - https://doi.org/10.1523/JNEUROSCI.3448-09.2010 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/84272/84272.pdf?sequence=1 ER - TY - JOUR AU - Ouden, H.E.M. den AU - Daunizeau, J. AU - Roiser, J. AU - Friston, K.J. AU - Stephan, K.E. PY - 2010 UR - https://hdl.handle.net/2066/89136 AB - Both perceptual inference and motor responses are shaped by learned probabilities. For example, stimulus-induced responses in sensory cortices and preparatory activity in premotor cortex reflect how (un)expected a stimulus is. This is in accordance with predictive coding accounts of brain function, which posit a fundamental role of prediction errors for learning and adaptive behavior. We used functional magnetic resonance imaging and recent advances in computational modeling to investigate how (failures of) learned predictions about visual stimuli influence subsequent motor responses. Healthy volunteers discriminated visual stimuli that were differentially predicted by auditory cues. Critically, the predictive strengths of cues varied over time, requiring subjects to continuously update estimates of stimulus probabilities. This online inference, modeled using a hierarchical Bayesian learner, was reflected behaviorally: speed and accuracy of motor responses increased significantly with predictability of the stimuli. We used nonlinear dynamic causal modeling to demonstrate that striatal prediction errors are used to tune functional coupling in cortical networks during learning. Specifically, the degree of striatal trial-by-trial prediction error activity controls the efficacy of visuomotor connections and thus the influence of surprising stimuli on premotor activity. This finding substantially advances our understanding of striatal function and provides direct empirical evidence for formal learning theories that posit a central role for prediction error-dependent plasticity. TI - Striatal prediction error modulates cortical coupling EP - 3219 SN - 0270-6474 IS - iss. 9 SP - 3210 JF - The Journal of Neuroscience VL - vol. 30 PS - 10 p. DO - https://doi.org/10.1523/JNEUROSCI.4458-09.2010 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/89136/89136.pdf?sequence=1 ER - TY - JOUR AU - Schouwenburg, M.R. van AU - Ouden, H.E.M. den AU - Cools, R. PY - 2010 UR - https://hdl.handle.net/2066/87832 AB - Current models of flexible cognitive control emphasize the role of the prefrontal cortex. This region has been shown to control attention by biasing information processing in favor of task-relevant representations. However, the prefrontal cortex does not act in isolation. We used functional magnetic resonance imaging combined with nonlinear dynamic causal modeling to demonstrate that the basal ganglia play a role in modulating the top-down influence of the prefrontal cortex on visual processing in humans. Specifically, our results reveal that connectivity between the prefrontal cortex and stimulus-specific visual association areas depends on activity in the ventral striatopallidum, elicited by salient events leading to shifts in attention. These data integrate disparate literatures on top-down control by the prefrontal cortex and selective gating by the basal ganglia and highlight the importance of the basal ganglia for high-level cognitive control. TI - The human basal ganglia modulate frontal-posterior connectivity during attention shifting EP - 9918 SN - 0270-6474 IS - iss. 29 SP - 9910 JF - The Journal of Neuroscience VL - vol. 30 PS - 9 p. DO - https://doi.org/10.1523/JNEUROSCI.1111-10.2010 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/87832/87832.pdf?sequence=1 ER - TY - JOUR AU - Elswijk, G.A.F. van AU - Maij, F. AU - Schoffelen, J.M. AU - Overeem, S. AU - Stegeman, D.F. AU - Fries, P. PY - 2010 UR - https://hdl.handle.net/2066/83675 AB - Rhythmic synchronization of neurons in the beta or gamma band occurs almost ubiquitously, and this synchronization has been linked to numerous nervous system functions. Many respective studies make the implicit assumption that neuronal synchronization affects neuronal interactions. Indeed, when neurons synchronize, their output spikes reach postsynaptic neurons together, trigger coincidence detection mechanisms, and therefore have an enhanced impact. There is ample experimental evidence demonstrating this consequence of neuronal synchronization, but beyond this, beta/gamma-band synchronization within a group of neurons might also modulate the impact of synaptic input to that synchronized group. This would constitute a separate mechanism through which synchronization affects neuronal interactions, but direct in vivo evidence for this putative mechanism is lacking. Here, we demonstrate that synchronized beta-band activity of a neuronal group modulates the efficacy of synaptic input to that group in-phase with the beta rhythm. This response modulation was not an addition of rhythmic activity onto the average response but a rhythmic modulation of multiplicative input gain. Our results demonstrate that beta-rhythmic activity of a neuronal target group multiplexes input gain along the rhythm cycle. The actual gain of an input then depends on the precision and the phase of its rhythmic synchronization to this target, providing one mechanistic explanation for why synchronization modulates interactions. TI - Corticospinal beta-band synchronization entails rhythmic gain modulation EP - 4488 SN - 0270-6474 IS - iss. 12 SP - 4481 JF - The Journal of Neuroscience VL - vol. 30 PS - 8 p. DO - https://doi.org/10.1523/JNEUROSCI.2794-09.2010 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/83675/83675.pdf?sequence=1 ER - TY - JOUR AU - Chen, G. AU - Zou, X. AU - Watanabe, H. AU - Deursen, J.M.A. van AU - Shen, J. PY - 2010 UR - https://hdl.handle.net/2066/88296 AB - CREB binding protein (CBP) is a transcriptional coactivator with histone acetyltransferase activity. Our prior study suggested that CBP might be a key target of presenilins in the regulation of memory formation and neuronal survival. To elucidate the role of CBP in the adult brain, we generated conditional knock-out (cKO) mice in which CBP is completely inactivated in excitatory neurons of the postnatal forebrain. Histological analysis revealed normal neuronal morphology and absence of age-dependent neuronal degeneration in the CBP cKO cerebral cortex. CBP cKO mice exhibited robust impairment in the formation of spatial, associative, and object-recognition memory. In addition to impaired long-term memory, CBP cKO mice also displayed deficits in short-term associative and object-recognition memory. Administration of a histone deacetylase inhibitor, trichostatin A, rescued the reduction of acetylated histones in the CBP cKO cortex but failed to rescue either short- or long-term memory deficits, suggesting that the memory impairment may not be caused by general reduction of histone acetyltransferase activity in CBP cKO mice. Further microarray and Western analysis showed decreased expression of calcium-calmodulin-dependent kinase isoforms and NMDA and AMPA receptor subunits in the cerebral cortex of CBP cKO mice. Collectively, these findings suggest a crucial role for CBP in the formation of both short- and long-term memory. TI - CREB binding protein is required for both short-term and long-term memory formation. EP - 13077 SN - 0270-6474 IS - iss. 39 SP - 13066 JF - The Journal of Neuroscience VL - vol. 30 DO - https://doi.org/10.1523/JNEUROSCI.2378-10.2010 L1 - https://repository.ubn.ru.nl/bitstream/handle/2066/88296/88296.pdf?sequence=1 ER -