Long-term outcome of placental site trophoblastic tumor in The Netherlands

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Title:	Long-term outcome of placental site trophoblastic tumor in The Netherlands
Author(s):	Trommel, N.E. van ; Lok, C.A.; Bulten, H. ; Thomas, C.M.G. ; Massuger, L.F.A.G.
Publication year:	2013
Source:	Journal of Reproductive Medicine, vol. 58, iss. 5-6, (2013), pp. 224-228
ISSN:	0024-7758
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/118744
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Subject:	IGMD 6: Hormonal regulation ONCOL 5: Aetiology, screening and detection ONCOL 1: Hereditary cancer and cancer-related syndromes ONCOL 3: Translational research ONCOL 5: Aetiology, screening and detection NCMLS 2: Immune Regulation ONCOL 3: Translational research
Organization:	Chemical Endocrinology Gynaecology Pathology Laboratory of Genetic, Endocrine and Metabolic Diseases
Journal title:	Journal of Reproductive Medicine
Volume:	vol. 58
Issue:	iss. 5-6
Page start:	p. 224
Page end:	p. 228
Abstract:	OBJECTIVE: To evaluate the outcome of 16 cases of placental site trophoblastic tumors (PSTTs) treated throughout The Netherlands. STUDY DESIGN: Patients with PSTT between 1991 and 2009 were identified using the nationwide network and registry of histopathology and cytopathology in The Netherlands (PALGA) and medical records. RESULTS: Data for 16 patients could be retrieved. The median age of the patients was 32 years. In 7 cases the antecedent pregnancy was a miscarriage and in 6, a term delivery. Clinical data on 3 patients could not be retrieved. Six patients were low-risk according to the International Federation of Gynecology and Obstetrics staging system. The median human chorionic gonadotropin (hCG) level was 46 IU/L, but in 4 patients the hCG level was not elevated. In the majority of patients a hysterectomy was performed, and 5 patients needed additional chemotherapy. There was only 1 recurrence and there were no fatalities. CONCLUSION: This study emphasizes the need for an international registration. No fatalities were registered. Because of the low incidence and limited experience of general gynecologists with this disease, there is a preference for centralization of all patients with PSTT regardless of their stage.