Iron metabolism in the pathogenesis of iron-induced kidney injury
SourceNature Reviews. Nephrology, 9, 7, (2013), pp. 385-398
Article / Letter to editor
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Laboratory of Genetic, Endocrine and Metabolic Diseases
Nature Reviews. Nephrology
SubjectIGMD 7: Iron metabolism N4i 1: Pathogenesis and modulation of inflammation; N4i 1 - pathogenesis and modulation of inflammation Oncol 5 - Aetiology, screening and detection; NCMLS 5: Membrane transport and intracellular motility IGMD 9: Renal disorder
In the past 8 years, there has been renewed interest in the role of iron in both acute kidney injury (AKI) and chronic kidney disease (CKD). In patients with kidney diseases, renal tubules are exposed to a high concentration of iron owing to increased glomerular filtration of iron and iron-containing proteins, including haemoglobin, transferrin and neutrophil gelatinase-associated lipocalin (NGAL). Levels of intracellular catalytic iron may increase when glomerular and renal tubular cells are injured. Reducing the excessive luminal or intracellular levels of iron in the kidney could be a promising approach to treat AKI and CKD. Understanding the role of iron in kidney injury and as a therapeutic target requires insight into the mechanisms of iron metabolism in the kidney, the role of endogenous proteins involved in iron chelation and transport, including hepcidin, NGAL, the NGAL receptor and divalent metal transporter 1, and iron-induced toxic effects. This Review summarizes emerging knowledge, which suggests that complex mechanisms of iron metabolism exist in the kidney, modulated directly or indirectly by cellular iron content, inflammation, ischaemia and oxidative stress. The potential exists for prevention and treatment of iron-induced kidney injury by customized iron removal or relocation, aided by detailed insight into the underlying pathological mechanisms.
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