Importance of helper T-cell activation in dendritic cell-based anticancer immunotherapy
SourceOncoimmunology, 2, 6, (2013), pp. e24440
Article / Letter to editor
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SubjectNCMLS 2: Immune Regulation; NCMLS 2: Immune Regulation ONCOL 3: Translational research; ONCOL 3: Translational research; ONCOL 3: Translational research NCMLS 2: Immune Regulation
Dendritic cell-based anticancer immunotherapy is feasible, safe and results in the induction of tumor-specific immune responses, at least in a fraction of vaccinated patients. The concomitant activation of cytotoxic and helper T cells, by loading DCs with peptides or electroporating them with the corresponding mRNAs, may further enhance vaccine-induced antitumor responses.
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