Identification of a novel human papillomavirus by metagenomic analysis of samples from patients with febrile respiratory illness
Publication year
2013Source
PLoS One, 8, 3, (2013), article e58404ISSN
Publication type
Article / Letter to editor

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Organization
CMBI
Journal title
PLoS One
Volume
vol. 8
Issue
iss. 3
Subject
NCMLS 4: Energy and redox metabolism IGMD 8: Mitochondrial medicineAbstract
As part of a virus discovery investigation using a metagenomic approach, a highly divergent novel Human papillomavirus type was identified in pooled convenience nasal/oropharyngeal swab samples collected from patients with febrile respiratory illness. Phylogenetic analysis of the whole genome and the L1 gene reveals that the new HPV identified in this study clusters with previously described gamma papillomaviruses, sharing only 61.1% (whole genome) and 63.1% (L1) sequence identity with its closest relative in the Papillomavirus episteme (PAVE) database. This new virus was named HPV_SD2 pending official classification. The complete genome of HPV-SD2 is 7,299 bp long (36.3% G/C) and contains 7 open reading frames (L2, L1, E6, E7, E1, E2 and E4) and a non-coding long control region (LCR) between L1 and E6. The metagenomic procedures, coupled with the bioinformatic methods described herein are well suited to detect small circular genomes such as those of human papillomaviruses.
This item appears in the following Collection(s)
- Academic publications [205104]
- Electronic publications [103316]
- Faculty of Medical Sciences [81055]
- Open Access publications [71820]
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