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Title: Identification of a novel human papillomavirus by metagenomic analysis of samples from patients with febrile respiratory illness
Author(s): Mokili, J.L.; Dutilh, B.E. ; Lim, Y.W.; Schneider, B.S.; Taylor, T.; Haynes, M.R.; Metzgar, D.; Myers, C.A.; Blair, P.J.; Nosrat, B.; Wolfe, N.D.; Rohwer, F.
Publication year: 2013
Source: PLoS One, vol. 8, iss. 3, (2013), pp. e58404
ISSN: 1932-6203
DOI: http://dx.doi.org/10.1371/journal.pone.0058404
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/118579   http://hdl.handle.net/2066/118579

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Subject: NCMLS 4: Energy and redox metabolism IGMD 8: Mitochondrial medicine
Organization: CMBI
Journal title:
PLoS One
Volume: vol. 8
Issue: iss. 3
Page start: p. e58404
Abstract:
As part of a virus discovery investigation using a metagenomic approach, a highly divergent novel Human papillomavirus type was identified in pooled convenience nasal/oropharyngeal swab samples collected from patients with febrile respiratory illness. Phylogenetic analysis of the whole genome and the L1 gene reveals that the new HPV identified in this study clusters with previously described gamma papillomaviruses, sharing only 61.1% (whole genome) and 63.1% (L1) sequence identity with its closest relative in the Papillomavirus episteme (PAVE) database. This new virus was named HPV_SD2 pending official classification. The complete genome of HPV-SD2 is 7,299 bp long (36.3% G/C) and contains 7 open reading frames (L2, L1, E6, E7, E1, E2 and E4) and a non-coding long control region (LCR) between L1 and E6. The metagenomic procedures, coupled with the bioinformatic methods described herein are well suited to detect small circular genomes such as those of human papillomaviruses.

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