Clinical management of drug-drug interactions in HCV therapy: Challenges and solutions
Publication year
2013Source
Journal of Hepatology, 58, 4, (2013), pp. 792-800ISSN
Publication type
Article / Letter to editor

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Organization
Clinical Pharmacy
Journal title
Journal of Hepatology
Volume
vol. 58
Issue
iss. 4
Page start
p. 792
Page end
p. 800
Subject
N4i 3: Poverty-related infectious diseases NCEBP 13: Infectious diseases and international healthAbstract
Hepatitis C virus (HCV) infected patients often take multiple co-medications to treat adverse events related to HCV therapy, or to manage other co-morbidities. Drug-drug interactions associated with this polypharmacy are relatively new to the field of HCV pharmacotherapy. With the advent of the direct-acting antivirals telaprevir and boceprevir, which are both substrates and inhibitors of the cytochrome P450 (CYP) 3A iso-enzyme, knowledge and awareness of drug-drug interactions have become a cornerstone in the evaluation of patients starting and continuing HCV combination therapy. In our opinion, an overview of conducted drug-drug interaction studies and a list of contraindicated medications is not enough for the clinical management of these drug-drug interactions. Knowledge of pharmacokinetic profiles and concentration-effect relationships is key for the interpretation of these data, and insight into how to manage these interactions (e.g., dose adjustments, safe alternatives and therapeutic drug monitoring) is of equal importance. This review provides a practical overview of the safe and effective management of these clinical challenges.
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- Academic publications [202923]
- Electronic publications [101091]
- Faculty of Medical Sciences [80072]
- Open Access publications [69755]
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