Publication year
2013Author(s)
Source
Nederlands Tijdschrift voor Geneeskunde, 157, 23, (2013), article A5725ISSN
Publication type
Article / Letter to editor

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Organization
Psychiatry
Journal title
Nederlands Tijdschrift voor Geneeskunde
Volume
vol. 157
Issue
iss. 23
Subject
DCN PAC - Perception action and controlAbstract
- This article describes the current scientific knowledge regarding pharmacogenetic predictors of treatment outcome for substance-dependent patients.- PubMed was searched for articles on pharmacogenetics and addiction. This search yielded 53 articles, of which 27 were selected.- The most promising pharmacogenetic findings are related to the treatment of alcohol dependence. Genetic variation in the micro-opioid receptor (OPRM1) and the serotonin transporter (5-HTTLPR) appear to be associated with treatment outcomes for naltrexone and ondansetron, respectively. - Genetic variation in CYP2D6 is related to efficacy of methadone treatment for opiate dependence. - Pharmacogenetics may help explain the great inter-individual variation in treatment response. In the future, treatment matching, based on genetic characteristics of individual patients, could lead to a 'personalized medicine' approach. Pharmacogenetic matching of naltrexone in alcohol-dependent carriers of the OPRM1 G-allele currently seems most promising.
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- Academic publications [227436]
- Faculty of Medical Sciences [86157]
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