Topographic hub maps of the human structural neocortical network
Publication year
2013Source
PLoS One, 8, 6, (2013), article e65511ISSN
Publication type
Article / Letter to editor
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Organization
PI Group MR Techniques in Brain Function
Anatomy
Journal title
PLoS One
Volume
vol. 8
Issue
iss. 6
Languages used
English (eng)
Subject
150 000 MR Techniques in Brain Function; DCN MP - Plasticity and memoryAbstract
Hubs within the neocortical structural network determined by graph theoretical analysis play a crucial role in brain function. We mapped neocortical hubs topographically, using a sample population of 63 young adults. Subjects were imaged with high resolution structural and diffusion weighted magnetic resonance imaging techniques. Multiple network configurations were then constructed per subject, using random parcellations to define the nodes and using fibre tractography to determine the connectivity between the nodes. The networks were analysed with graph theoretical measures. Our results give reference maps of hub distribution measured with betweenness centrality and node degree. The loci of the hubs correspond with key areas from known overlapping cognitive networks. Several hubs were asymmetrically organized across hemispheres. Furthermore, females have hubs with higher betweenness centrality and males have hubs with higher node degree. Female networks have higher small-world indices.
This item appears in the following Collection(s)
- Academic publications [243984]
- Donders Centre for Cognitive Neuroimaging [3983]
- Electronic publications [130873]
- Faculty of Medical Sciences [92811]
- Open Access publications [105042]
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