The Multiple Faces of Prostaglandin E2 G-Protein Coupled Receptor Signaling during the Dendritic Cell Life Cycle
Publication year
2013Source
International Journal of Molecular Sciences, 14, 4, (2013), pp. 6542-55ISSN
Publication type
Article / Letter to editor
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Organization
Tumorimmunology
Journal title
International Journal of Molecular Sciences
Volume
vol. 14
Issue
iss. 4
Page start
p. 6542
Page end
p. 55
Subject
NCMLS 2: Immune Regulation; NCMLS 3: Tissue engineering and pathologyAbstract
Many processes regulating immune responses are initiated by G-protein coupled receptors (GPCRs) and report biochemical changes in the microenvironment. Dendritic cells (DCs) are the most potent antigen-presenting cells and crucial for the regulation of innate and adaptive immune responses. The lipid mediator Prostaglandin E2 (PGE2) via four GPCR subtypes (EP1-4) critically regulates DC generation, maturation and migration. The role of PGE2 signaling in DC biology was unraveled by the characterization of EP receptor subtype expression in DC progenitor cells and DCs, the identification of the signaling pathways initiated by these GPCR subtypes and the classification of DC responses to PGE2 at different stages of differentiation. Here, we review the advances in PGE2 signaling in DCs and describe the efforts still to be made to understand the spatio-temporal fine-tuning of PGE2 responses by DCs.
This item appears in the following Collection(s)
- Academic publications [238441]
- Electronic publications [122544]
- Faculty of Medical Sciences [90373]
- Open Access publications [97535]
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