Recommendations for pregnancies in patients with crigler-najjar syndrome
SourceJimd Reports, 7, (2013), pp. 59-62
Article / Letter to editor
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SubjectNCEBP 14: Cardiovascular diseases IGMD 6: Hormonal regulation
During pregnancy, the developing foetus in mothers with Crigler-Najjar type 1 and 2 is exposed to raised levels of unconjugated bilirubin, with the risk of neurotoxicity. We describe two pregnancies in a patient with Crigler-Najjar type 2, who was carefully monitored prior to and during pregnancy and phototherapy adjusted to maintain serum bilirubin levels below 200 mumol/l and the bilirubin/albumin molar ratio below 50%. Both pregnancies resulted in normal delivery of healthy infants who had normal neurological development. A review of all reported pregnancies in Crigler-Najjar patients and a set of recommendations are presented.
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