Publication year
2013Source
British Journal of Cancer, 108, 9, (2013), pp. 1784-9ISSN
Publication type
Article / Letter to editor
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Organization
Radiation Oncology
Urology
Health Evidence
Former Organization
Epidemiology, Biostatistics & HTA
Journal title
British Journal of Cancer
Volume
vol. 108
Issue
iss. 9
Page start
p. 1784
Page end
p. 9
Subject
NCEBP 1: Molecular epidemiology; NCEBP 2:Evaluation of complex medical interventions ONCOL 4:Quality of Care; ONCOL 3: Translational research; ONCOL 4: Quality of Care; ONCOL 5: Aetiology, screening and detectionAbstract
Background:Previous studies on the effects of different prostate cancer treatments on quality of life, were confounded because patients were not comparable. This study examined treatment effects in more comparable groups.Methods:From 2008-2011, 240 patients with localised prostate cancer were selected to be eligible for both radical prostatectomy (RP) and external beam radiotherapy (EBRT). Brachytherapy (BT) was a third option for some. Health-related quality of life was measured by expanded prostate cancer index composite (EPIC) up to 12 months after treatment.Results:In the sexual domain, RP led to worse summary scores (P<0.001) and more often to a clinically relevant deterioration from baseline than BT and EBRT (79%, 33%, 34%, respectively). In the urinary domain, RP also led to worse summary scores (P=0.014), and more deterioration from baseline (41%, 12%, 19%, respectively). Only on the irritative/obstructive urinary scale, more BT patients (40%) showed a relevant deterioration than RP (17%) and EBRT patients (11%). In the bowel domain, the treatment effects did not differ.Conclusion:This study provides a more unbiased comparison of treatment effects, as men were more comparable at baseline. Our results suggest that, for quality of life, radiotherapy is as least as good an option as RP for treating localised prostate cancer.
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- Faculty of Medical Sciences [90359]
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