Prognostic biological features in neck dissection specimens
SourceEuropean Archives of Oto-Rhino-Laryngology, 270, 5, (2013), pp. 1581-1592
Article / Letter to editor
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European Archives of Oto-Rhino-Laryngology
SubjectONCOL 3: Translational research
The superior prognostic value offered by routine histopathological staging of neck dissections, as compared to clinical staging using palpation and modern imaging techniques, is well established in the literature concerning the management of squamous cell carcinoma of the head and neck. In this review, we discuss the definitions and criteria used in standardised routine histopathological reporting and explore additional potential nodal prognostic features. In addition, we critically appraise the value of immunohistochemistry, histochemistry, molecular and other non-morphological techniques and suggest tumour and host features that merit further investigations.
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