Genome-wide association uncovers shared genetic effects among personality traits and mood states

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Title:	Genome-wide association uncovers shared genetic effects among personality traits and mood states
Author(s):	Luciano, M.; Huffman, J.E.; Arias-Vasquez, A.; Vinkhuyzen, A.A.E.; Middeldorp, C.M.; Giegling, I.; Payton, A.; Davies, G.; Zgaga, L.; Janzing, J.G.E. ; Ke, X. ; Galesloot, T.E.; Hartmann, A.M.; Ollier, W.; Tenesa, A.; Hayward, C.; Verhagen, M. ; Montgomery, G.W.; Hottenga, J.J.; Konte, B.; Starr, J.M.; Vitart, V.; Vos, P.E. ; Madden, P.A.F.; Willemsen, G.; Konnerth, H.; Horan, M.A.; Porteous, D.J.; Campbell, H.; Vermeulen, H.H.M. ; Heath, A.C.; Wright, A.J.; Polasek, O.; Kovacevic, S.B.; Hastie, N.D.; Franke, B. ; Boomsma, D.I. ; Martin, N.G.; Rujescu, D.; Wilson, J.F.; Buitelaar, J.K. ; Pendleton, N.; Rudan, I.; Deary, I.J.
Publication year:	2012
Source:	American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, vol. 159B, iss. 6, (2012), pp. 684-695
Number of Pages:	12 p.
ISSN:	1552-4841
DOI:	http://dx.doi.org/10.1002/ajmg.b.32072
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/116809
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Subject:	Developmental Psychopathology
Organization:	FSW_Fac. algemeen SW OZ BSI OGG
Journal title:	American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics
Volume:	vol. 159B
Issue:	iss. 6
Page start:	p. 684
Page end:	p. 695
Abstract:	Measures of personality and psychological distress are correlated and exhibit genetic covariance. We conducted univariate genome-wide SNP (∼2.5 million) and gene-based association analyses of these traits and examined the overlap in results across traits, including a prediction analysis of mood states using genetic polygenic scores for personality. Measures of neuroticism, extraversion, and symptoms of anxiety, depression, and general psychological distress were collected in eight European cohorts (n ranged 546–1,338; maximum total n = 6,268) whose mean age ranged from 55 to 79 years. Meta-analysis of the cohort results was performed, with follow-up associations of the top SNPs and genes investigated in independent cohorts (n = 527–6,032). Suggestive association (P = 8 × 10−8) of rs1079196 in the FHIT gene was observed with symptoms of anxiety. Other notable associations (P < 6.09 × 10−6) included SNPs in five genes for neuroticism (LCE3C, POLR3A, LMAN1L, ULK3, SCAMP2), KIAA0802 for extraversion, and NOS1 for general psychological distress. An association between symptoms of depression and rs7582472 (near to MGAT5 and NCKAP5) was replicated in two independent samples, but other replication findings were less consistent. Gene-based tests identified a significant locus on chromosome 15 (spanning five genes) associated with neuroticism which replicated (P < 0.05) in an independent cohort. Support for common genetic effects among personality and mood (particularly neuroticism and depressive symptoms) was found in terms of SNP association overlap and polygenic score prediction. The variance explained by individual SNPs was very small (up to 1%) confirming that there are no moderate/large effects of common SNPs on personality and related traits