The pathophysiology of essential tremor and Parkinson's tremor
Number of pages
SourceCurrent Neurology and Neuroscience Reports, 13, 9, (2013), article 378
Article / Letter to editor
Display more detailsDisplay less details
PI Group Systems Neurology
PI Group Intention and Action
SW OZ DCC CO
F.C. Donders Centre for Cognitive Neuroimaging
Current Neurology and Neuroscience Reports
Subject111 000 Intention & Action; Action, intention, and motor control; DCN MP - Plasticity and memory; DCN MP - Plasticity and memory NCEBP 10: Human Movement & Fatigue; DI-BCB_DCC_Theme 2: Perception, Action and Control
We review recent evidence about the pathophysiology of essential tremor and tremor in Parkinson’s disease. We believe that a network perspective is necessary to understand this common neurological symptom, and that knowledge of cerebral network dysfunction in tremor disorders will help to develop new therapies. Both essential tremor and Parkinson’s tremor are associated with increased activity in the cerebellothalamocortical circuit. However, different pathophysiological mechanisms lead to tremulous activity within this circuit. In Parkinson’s disease, evidence suggests that dopaminergic dysfunction of the pallidum triggers increased activity in the cerebellothalamocortical circuit. In essential tremor, GABAergic dysfunction of the cerebellar dentate nucleus and brain stem, possibly caused by neurodegeneration in these regions, may lead to tremulous activity within the cerebellothalamocortical circuit. In both disorders, network parameters such as the strength and directionality of interregional coupling are crucially altered. Exciting new research uses these network parameters to develop network-based therapies, such as closed-loop deep brain stimulation and transcranial magnetic or direct current stimulation.
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.