Reduced serotonin transporter availability decreases prefrontal control of the amygdala
SourceThe Journal of Neuroscience, 33, 21, (2013), pp. 8974-8979
Article / Letter to editor
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SW OZ BSI KLP
PI Group Intention and Action
PI Group Motivational & Cognitive Control
PI Group Memory and Emotion
SW OZ DCC CO
PI Group Affective Neuroscience
F.C. Donders Centre for Cognitive Neuroimaging
The Journal of Neuroscience
Subject111 000 Intention & Action; 130 000 Cognitive Neurology & Memory; 230 Affective Neuroscience; Action, intention, and motor control; DCN MP - Plasticity and memory; DCN PAC - Perception action and control IGMD 3: Genomic disorders and inherited multi-system disorders; DI-BCB_DCC_Theme 2: Perception, Action and Control; Experimental Psychopathology and Treatment; IGMD 3: Genomic disorders and inherited multi-system disorders DCN MP - Plasticity and memory; ONCOL 3: Translational research NCMLS 2: Immune Regulation
After a threatening event, the risk of developing social psychopathologies is increased in short-allele (s) carriers of the serotonin transporter gene. The amygdala becomes overresponsive to emotional stimuli, an effect that could be driven by local hypersensitivity or by reduced prefrontal regulation. This study distinguishes between these two hypotheses by using dynamic causal modeling of fMRI data acquired in a preselected cohort of human s-carriers and homozygous long-allele carriers. Increased amygdala activity in s-carriers originates from reduced prefrontal inhibitory regulation when social emotional behavior needs to be controlled, suggesting a mechanism for increased vulnerability to psychopathologies.
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