Default Mode Network Connectivity in Stroke Patients
Number of pages
SourcePLoS One, 8, 6, (2013), article e66556
Article / Letter to editor
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Donders Centre for Cognitive Neuroimaging
PI Group MR Techniques in Brain Function
F.C. Donders Centre for Cognitive Neuroimaging
Subject130 000 Cognitive Neurology & Memory; 150 000 MR Techniques in Brain Function; Biophysics; DCN MP - Plasticity and memory; DCN MP - Plasticity and memory NCEBP 14: Cardiovascular diseases; DCN MP - Plasticity and memory NCEBP 9 - Mental Health; DCN NN - Brain networks and neuronal communication NCEBP 9 - Mental health; ONCOL 3: Translational research NCMLS 2: Immune Regulation
The pathophysiology of episodic memory dysfunction after infarction is not completely understood. It has been suggested that infarctions located anywhere in the brain can induce widespread effects causing disruption of functional networks of the cortical regions. The default mode network, which includes the medial temporal lobe, is a functional network that is associated with episodic memory processing. We investigated whether the default mode network activity is reduced in stroke patients compared to healthy control subjects in the resting state condition. We assessed the whole brain network properties during resting state functional MRI in 21 control subjects and 20 'first-ever' stroke patients. Patients were scanned 9-12 weeks after stroke onset. Stroke lesions were located in various parts of the brain. Independent component analyses were conducted to identify the default mode network and to compare the group differences of the default mode network. Furthermore, region-of-interest based analysis was performed to explore the functional connectivity between the regions of the default mode network. Stroke patients performed significantly worse than control subjects on the delayed recall score on California verbal learning test. We found decreased functional connectivity in the left medial temporal lobe, posterior cingulate and medial prefrontal cortical areas within the default mode network and reduced functional connectivity between these regions in stroke patients compared with controls. There were no significant volumetric differences between the groups. These results demonstrate that connectivity within the default mode network is reduced in 'first-ever' stroke patients compared to control subjects. This phenomenon might explain the occurrence of post-stroke cognitive dysfunction in stroke patients.
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