Economic evaluation of endothelial keratoplasty techniques and penetrating keratoplasty in the Netherlands.
Publication year
2012Source
American Journal of Ophthalmology, 154, 2, (2012), pp. 272-281.e2ISSN
Annotation
01 augustus 2012
Publication type
Article / Letter to editor

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Organization
Ophthalmology
Journal title
American Journal of Ophthalmology
Volume
vol. 154
Issue
iss. 2
Page start
p. 272
Page end
p. 281.e2
Subject
NCEBP 2: Evaluation of complex medical interventionsAbstract
PURPOSE: To evaluate cost-effectiveness of penetrating keratoplasty (PK), femtosecond laser-assisted Descemet stripping endothelial keratoplasty (FS-DSEK), and Descemet stripping automated endothelial keratoplasty (DSAEK). DESIGN: Cost-effectiveness analysis based on data from a randomized multicenter clinical trial and a noncomparative prospective study. METHODS: Data of 118 patients with corneal endothelial dysfunction were analyzed in the economic evaluation. Forty patients were included in the PK group, 36 in the FS-DSEK group, and 42 in the DSAEK group. The primary incremental cost-effectiveness ratio (ICER) was the incremental costs per clinically improved patient, defined as a patient with a combined effectiveness of both a clinically improved BSCVA (defined as an improvement of at least 2 lines) and a clinically acceptable refractive astigmatism (defined as less than or equal to 3.0 diopters). Analysis was based on a 1-year follow-up period after transplantation. RESULTS: The percentage of treated patients who met the combined effectiveness measures was 52% for DSAEK, 44% for PK, and 43% for FS-DSEK. Mean total costs per patient were euro6674 (US$7942), euro12 443 (US$14 807), and euro7072 (US$8416) in the PK group, FS-DSEK group, and DSAEK group, respectively. FS-DSEK was less effective and more costly compared to both DSAEK and PK. DSAEK was more costly but also more effective compared to PK, resulting in incremental costs of euro4975 (US$5920) per additional clinically improved patient. CONCLUSIONS: The results of this study show that FS-DSEK was not cost-effective compared to PK and DSAEK. DSAEK, on the other hand, was more costly but also more effective compared to PK. Including societal costs, a longer follow-up period and preparation of the lamellar transplant buttons in a national cornea bank could improve the cost-effectiveness of DSAEK.
This item appears in the following Collection(s)
- Academic publications [227900]
- Faculty of Medical Sciences [86236]
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