EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue: a case report.

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Title:	EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue: a case report.
Author(s):	Flucke, U.E. ; Mentzel, T.; Verdijk, M.A.J.; Slootweg, P.J. ; Creytens, D.H.; Suurmeijer, A.J.H.; Tops, B.B.J.
Publication year:	2012
Source:	Human Pathology, vol. 43, iss. 5, (2012), pp. 764-768
ISSN:	0046-8177
DOI:	https://doi.org/10.1016/j.humpath.2011.08.004
Annotation:	1 mei 2012
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/111016
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Subject:	ONCOL 3: Translational research
Organization:	Pathology
Journal title:	Human Pathology
Volume:	vol. 43
Issue:	iss. 5
Page start:	p. 764
Page end:	p. 768
Abstract:	Soft tissue myoepithelial tumors, a recently defined entity, include benign and malignant lesions showing a considerable morphological and immunohistochemical heterogeneity. EWSR1 rearrangements are well recognized in this tumor type, and some of the partner genes have been identified. Herein we describe a soft tissue myoepithelioma arising in the pelvis with an EWSR1-ATF1 fusion, therefore extending the spectrum of partner genes of EWSR1. In addition, this case indicates that there are overlapping genetic features of myoepithelial tumors, clear cell sarcoma, angiomatoid fibrous histiocytoma, and hyalinizing clear-cell carcinoma of the salivary gland.