Distinct neural correlates of associative working memory and long-term memory encoding in the medial temporal lobe
Publication year
2012Number of pages
9 p.
Source
NeuroImage, 63, 2, (2012), pp. 989-997ISSN
Publication type
Article / Letter to editor
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Organization
SW OZ DCC NRP
Nuclear Medicine
Cognitive Neuroscience
Medical Psychology
Journal title
NeuroImage
Volume
vol. 63
Issue
iss. 2
Languages used
English (eng)
Page start
p. 989
Page end
p. 997
Subject
DCN MP - Plasticity and memory; DI-BCB_DCC_Theme 3: Plasticity and Memory; NCEBP 8 - Psychological determinants of chronic illness DCN PAC - Perception action and control; Neuropsychology and rehabilitation psychology; ONCOL 3: Translational research NCMLS 2: Immune Regulation; Medical Imaging - Radboud University Medical Center; Neuro- en revalidatiepsychologieAbstract
Increasing evidence suggests a role for the hippocampus not only in long-term memory (LTM) but also in relational working memory (WM) processes, challenging the view of the hippocampus as being solely involved in episodic LTM. However, hippocampal involvement reported in some neuroimaging studies using "classical" WM tasks may at least partly reflect incidental LTM encoding. To disentangle WM processing and LTM formation we administered a delayed-match-to-sample associative WM task in an event-related fMRI study design. Each trial of the WM task consisted of four pairs of faces and houses, which had to be maintained during a delay of 10 s. This was followed by a probe phase consisting of three consecutively presented pairs; for each pair participants were to indicate whether it matched one of the pairs of the encoding phase. After scanning, an unexpected recognition-memory (LTM) task was administered. Brain activity during encoding was analyzed based on WM and LTM performance. Hence, encoding-related activity predicting WM success in the absence of successful LTM formation could be isolated. Furthermore, regions critical for successful LTM formation for pairs previously correctly processed in WM were analyzed. Results showed that the left parahippocampal gyrus including the fusiform gyrus predicted subsequent accuracy on WM decisions. The right anterior hippocampus and left inferior frontal gyrus, in contrast, predicted successful LTM for pairs that were previously correctly classified in the WM task. Our results suggest that brain regions associated with higher-level visuo-perceptual processing are involved in successful associative WM encoding, whereas the anterior hippocampus and left inferior frontal gyrus are involved in successful LTM formation during incidental encoding.
This item appears in the following Collection(s)
- Academic publications [243859]
- Faculty of Medical Sciences [92795]
- Faculty of Social Sciences [30014]
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