Different patterns of Toll-like receptor 2 polymorphisms in populations of various ethnic and geographic origins.
Publication year
2012Source
Infection and Immunity, 80, 5, (2012), pp. 1917-1922ISSN
Annotation
1 mei 2012
Publication type
Article / Letter to editor

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Organization
Internal Medicine
Medical Microbiology
Journal title
Infection and Immunity
Volume
vol. 80
Issue
iss. 5
Page start
p. 1917
Page end
p. 1922
Subject
N4i 1: Pathogenesis and modulation of inflammation; N4i 1: Pathogenesis and modulation of inflammation NCMLS 1: Infection and autoimmunity; N4i 2: Invasive mycoses and compromised host; N4i 3: Poverty-related infectious diseases NCEBP 13: Infectious diseases and international health; N4i 3: Poverty-related infectious diseases NCMLS 1: Infection and autoimmunity; N4i 3: Poverty-related infectious diseases NCMLS 1: Infection and autoimmunityAbstract
Upon the invasion of the host by microorganisms, innate immunity is triggered through pathogen recognition by pattern recognition receptors (PRRs). Toll-like receptors (TLRs) are the best-studied class of PRRs, and they recognize specific pathogen-associated molecular patterns (PAMPs) from various microorganisms. A large number of studies have shown that genetic variation in TLRs may influence susceptibility to infections. We assessed the genetic variation of TLR2, which encodes one of the most important TLRs, in various populations around the globe and correlated it with changes in the function of the molecule. The three best-known nonsynonymous TLR2 polymorphisms (1892C>A, 2029C>T, and 2258G>A) were assessed in different populations from the main continental masses: Romanians, Vlax-Roma, Dutch (European populations), Han Chinese (East Asia), Dogon, Fulani (Africa), and Trio Indians (America). The 2029C>T polymorphism was absent in both European and non-European populations, with the exception of the Vlax-Roma, suggesting that this polymorphism most likely arose in Indo-Aryan people after migration into South Asia. The 1892C>A polymorphism that was found exclusively in European populations, but not in Asian, African, or American volunteers, probably occurred in proto-Indo-Europeans. Interestingly, 2258G>A was present only in Europeans, including Vlax-Roma, but at a very low frequency. The differential pattern of the TLR2 polymorphisms in various populations may explain some of the differences in susceptibility to infections between these populations.
This item appears in the following Collection(s)
- Academic publications [202736]
- Faculty of Medical Sciences [79998]
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