Detection, characterization, and screening of heme-binding molecules by mass spectrometry for malaria drug discovery
SourceAnalytica Chimica Acta, 84, 7, (2012), pp. 3324-9
Article / Letter to editor
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Analytica Chimica Acta
SubjectN4i 1: Pathogenesis and modulation of inflammation
Drug screening for antimalarials uses heme biocrystallization inhibition methods as an alternative to parasite cultures, but they involve complex processes and cannot detect artemisinin-like molecules. The described method detects heme-binding compounds by mass spectrometry, using dissociation of the drug-heme adducts to evaluate putative antiplasmodial activity. Applied to a chemical library, it showed a good hit-to-lead ratio and is an efficient early stage screening for complex mixtures like natural extracts.
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