Centralised multidisciplinary re-evaluation of diagnostic procedures in patients with newly diagnosed Hodgkin lymphoma

Fulltext:
110506.pdf
Embargo:
until further notice
Size:
187.5Kb
Format:
PDF
Description:
publisher's version
Publication year
2012Source
Annals of Oncology, 23, 10, (2012), pp. 2676-81ISSN
Publication type
Article / Letter to editor

Display more detailsDisplay less details
Organization
Haematology
Pathology
Radiology
Nuclear Medicine
Radiation Oncology
Journal title
Annals of Oncology
Volume
vol. 23
Issue
iss. 10
Page start
p. 2676
Page end
p. 81
Subject
N4i 2: Invasive mycoses and compromised host ONCOL 3: Translational research; ONCOL 3: Translational research; ONCOL 3: Translational research NCMLS 3: Tissue engineering and pathology; ONCOL 5: Aetiology, screening and detectionAbstract
Background Hodgkin Lymphoma (HL) is highly curable when treated accurately. The challenge is to cure patients with the minimal risk of long-term complications. For that, optimal initial diagnostics are required to determine the optimal treatment plan. We offer non-academic hospitals in our Regional Comprehensive Cancer Centre network a centralised review of all diagnostic procedures from patients with newly diagnosed HL. We report our experience on concordances and discrepancies between local findings and central review results. Patients and methods A haematologist and radiation oncologist at the Hodgkin Radboud University Nijmegen Medical Centre outpatient clinic examined all patients with newly diagnosed HL between February 2006 and May 2010. In a multidisciplinary lymphoma conference, diagnostic information is reviewed and treatment advice formulated. Discordant findings in pathology, staging and therapy were recorded as 'minor', no therapeutic consequences or 'major', adapted therapy advice. Results Altogether, 125 patients were included. Pathology review showed 86% concordance, with 4% major discordance, mainly nodular lymphocyte predominant sub-type. Revision of initial staging was concordant in 77%; however 15% major discordance of which most were upstaged. This resulted in 19% treatment adaption. Conclusion Our findings highlight the discrepancies in interpretation of diagnostic tests. We advocate centralised review process for all newly diagnosed patients with HL.
This item appears in the following Collection(s)
- Academic publications [227881]
- Electronic publications [107344]
- Faculty of Medical Sciences [86219]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.