Biological mechanisms influencing prosthetic bypass graft patency: possible targets for modern graft design.

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Title:	Biological mechanisms influencing prosthetic bypass graft patency: possible targets for modern graft design.
Author(s):	Scharn, D.M. ; Daamen, W.F. ; Kuppevelt, T. van ; Vliet, J.A. van der
Publication year:	2012
Source:	European Journal of Vascular and Endovascular Surgery, vol. 43, iss. 1, (2012), pp. 66-72
ISSN:	1078-5884
DOI:	http://dx.doi.org/10.1016/j.ejvs.2011.09.009
Annotation:	1 januari 2012
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/110401
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Subject:	NCEBP 14: Cardiovascular diseases NCMLS 3: Tissue engineering and pathology NCMLS 3: Tissue engineering and pathology ONCOL 3: Translational research
Organization:	Surgery Biochemistry (UMC)
Journal title:	European Journal of Vascular and Endovascular Surgery
Volume:	vol. 43
Issue:	iss. 1
Page start:	p. 66
Page end:	p. 72
Abstract:	In recent years, ample attention has been directed towards the mechanisms that play a major role in the process of vascular graft failure, especially graft thrombosis and intimal narrowing have been highlighted. In this article, a survey is conducted into the key mechanisms of the biological processes of intimal hyperplasia and ultimate graft failure. The sequence of biochemical events that lead to thrombosis of grafts is used as a guideline to describe possible counteracting prosthetic surface interventions in each separate phase of the process.