Tubulin Tyrosine Ligase Like 12, a TTLL Family Member with SET- and TTL-Like Domains and Roles in Histone and Tubulin Modifications and Mitosis
Publication year
2012Source
PLoS One, 7, 12, (2012), article e51258ISSN
Publication type
Article / Letter to editor
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Organization
Urology
Journal title
PLoS One
Volume
vol. 7
Issue
iss. 12
Subject
ONCOL 3: Translational research NCMLS 6: Genetics and epigenetic pathways of diseaseAbstract
hTTLL12 is a member of the tubulin tyrosine ligase (TTL) family that is highly conserved in phylogeny. It has both SET-like and TTL-like domains, suggesting that it could have histone methylation and tubulin tyrosine ligase activities. Altered expression of hTTLL12 in human cells leads to specific changes in H4K20 trimethylation, and tubulin detyrosination, hTTLL12 does not catalyse histone methylation or tubulin tyrosination in vitro, as might be expected from the lack of critical amino acids in its SET-like and TTLL-like domains. hTTLL12 misexpression increases mitotic duration and chromosome numbers. These results suggest that hTTLL12 has non-catalytic functions related to tubulin and histone modification, which could be linked to its effects on mitosis and chromosome number stability.
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- Academic publications [245263]
- Electronic publications [132514]
- Faculty of Medical Sciences [93208]
- Open Access publications [106157]
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