Association between thyroid function, thyroid autoimmunity, and state and trait factors of depression
SourceActa Psychiatrica Scandinavica, 126, 5, (2012), pp. 377-384
Article / Letter to editor
Display more detailsDisplay less details
Laboratory of Genetic, Endocrine and Metabolic Diseases
PI Group Memory and Emotion
Epidemiology, Biostatistics & HTA
F.C. Donders Centre for Cognitive Neuroimaging
Acta Psychiatrica Scandinavica
SubjectDCN NN - Brain networks and neuronal communication; DCN PAC - Perception action and control; DCN PAC - Perception action and control NCEBP 9 - Mental health; IGMD 5: Health aging / healthy living NCEBP 14: Cardiovascular diseases; IGMD 6: Hormonal regulation; IGMD 6: Hormonal regulation ONCOL 3: Translational research; IGMD 6: Hormonal regulation ONCOL 5: Aetiology, screening and detection; NCEBP 1: Molecular epidemiology ONCOL 5: Aetiology, screening and detection; NCEBP 9: Mental health; IGMD 6: Hormonal regulation NCEBP 1: Molecular epidemiology; ONCOL 5: Aetiology, screening and detection
van de Ven AC, Muntjewerff J-W, Netea-Maier RT, de Vegt F, Ross HA, Sweep FCGJ, Kiemeney LA, Vos PE, Buitelaar JK, Hermus ARMM, den Heijer M, Janzing JGE. Association between thyroid function, thyroid autoimmunity, and state and trait factors of depression. Objective: The aim of this study was to investigate whether thyroid function and thyroid peroxidase antibodies (TPOAb) are associated with depression, when using both state and trait parameters of depression. Method: In 1125 participants of the Nijmegen Biomedical Study, thyroid-stimulating hormone (TSH), free thyroxine (FT(4) ), and TPOAb were measured twice. The Beck Depression Inventory (BDI), a self-reported lifetime diagnosis of depression, and the neuroticism scale of the Eysenck Personality Questionnaire Revised Short Scale (EPQ-RSS) were used to evaluate the presence of state and trait features of depression. Results: We found no association between TSH and FT(4) levels and BDI score, current depression, lifetime diagnosis of depression, and EPQ-RSS neuroticism score. Subjects with TPOAb had higher EPQ-RSS neuroticism scores in comparison with subjects without TPOAb, mean score 4.1 vs. 3.2 (regression coefficient 0.70; 95% CI 0.1-1.3; P-value 0.02 after adjustment for confounders). The prevalence of a lifetime diagnosis of depression was higher in subjects with positive TPOAb in comparison with participants without TPOAb: 24.2% vs. 16.7% (relative risk 1.4; 95% CI 1.0-2.1; P-value 0.04 after adjustment for confounders). Conclusion: Thyroid peroxidase antibodies are positively associated with trait markers of depression. The presence of TPOAb may be a vulnerability marker for depression.
Upload full text
Use your RU credentials (u/z-number and password) tolog in with SURFconextto upload a file for processing by the repository team.