The relationship between lung function impairment and quantitative computed tomography in chronic obstructive pulmonary disease.
SourceEuropean Radiology, 22, 1, (2012), pp. 120-8
01 januari 2012
Article / Letter to editor
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SubjectN4i 3: Poverty-related infectious diseases ONCOL 5: Aetiology, screening and detection; ONCOL 5: Aetiology, screening and detection; NCEBP 14: Cardiovascular diseases ONCOL 5: Aetiology, screening and detection
OBJECTIVES: To determine the relationship between lung function impairment and quantitative computed tomography (CT) measurements of air trapping and emphysema in a population of current and former heavy smokers with and without airflow limitation. METHODS: In 248 subjects (50 normal smokers; 50 mild obstruction; 50 moderate obstruction; 50 severe obstruction; 48 very severe obstruction) CT emphysema and CT air trapping were quantified on paired inspiratory and end-expiratory CT examinations using several available quantification methods. CT measurements were related to lung function (FEV(1), FEV(1)/FVC, RV/TLC, Kco) by univariate and multivariate linear regression analysis. RESULTS: Quantitative CT measurements of emphysema and air trapping were strongly correlated to airflow limitation (univariate r-squared up to 0.72, p < 0.001). In multivariate analysis, the combination of CT emphysema and CT air trapping explained 68-83% of the variability in airflow limitation in subjects covering the total range of airflow limitation (p < 0.001). CONCLUSIONS: The combination of quantitative CT air trapping and emphysema measurements is strongly associated with lung function impairment in current and former heavy smokers with a wide range of airflow limitation.
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