Short-term statin treatment does not prevent ischemia and reperfusion-induced endothelial dysfunction in humans.
Publication year
2012Source
Journal of Cardiovascular Pharmacology, 59, 1, (2012), pp. 22-8ISSN
Annotation
01 januari 2012
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
Cardiology
Surgery
Gynaecology
Physiology
Paediatrics - OUD tm 2017
Internal Medicine
Pharmacology-Toxicology
Journal title
Journal of Cardiovascular Pharmacology
Volume
vol. 59
Issue
iss. 1
Page start
p. 22
Page end
p. 8
Subject
NCEBP 14: Cardiovascular diseases; NCEBP 14: Cardiovascular diseases IGMD 5: Health aging / healthy living; ONCOL 5: Aetiology, screening and detectionAbstract
Statins are known to have cholesterol-independent pleiotropic effects, such as upregulation of the enzyme ecto-5'-nucleotidase. These effects may contribute to the protective effect of statins against ischemia and reperfusion (IR). Interestingly, pleiotropic effects have been shown to differ between hydrophilic and lipophilic statins. Flow-mediated dilation (FMD) represents a largely nitric oxide-mediated, endothelium-dependent dilation and has been shown to decrease after exposure to IR in humans. FMD has been validated to study (pharmacological) interventions in IR injury. We examined the effect of a short-term (3-7 days) statin pretreatment on brachial artery endothelial function before and after IR, and whether the effect on brachial artery endothelial function differs between rosuvastatin (hydrophilic statin) and atorvastatin (lipophilic statin). Our results show that IR significantly decreases FMD; however, statin pretreatment did not alter the effect of IR on FMD (irrespective of treatment duration or type of statin used). This experiment suggests that the cardioprotective effects of statins (both lipophilic and hydrophilic) against IR are not mediated through preservation of endothelial function.
This item appears in the following Collection(s)
- Academic publications [238430]
- Faculty of Medical Sciences [90359]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.