STATing the importance of immune modulation by platinum chemotherapeutics.
SourceOncoimmunology, 1, 2, (2012), pp. 234-236
Article / Letter to editor
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SubjectNCMLS 2: Immune Regulation; ONCOL 3: Translational research NCMLS 2: Immune Regulation
Platinum-based anticancer drugs enhance the immunostimulatory potential of DCs and decrease the immunosuppressive capacity of tumor cells. This immunomodulatory ability is based on the inhibition of STAT6-mediated expression of co-inhibitory molecule PD-L2 and opens up the possibility of using these drugs in combination with other immunostimulatory compounds.
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