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Publication year
2012Source
Nephron. Clinical Practice, 120, 3, (2012), pp. c156-61ISSN
Publication type
Article / Letter to editor
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Organization
Gynaecology
Journal title
Nephron. Clinical Practice
Volume
vol. 120
Issue
iss. 3
Page start
p. c156
Page end
p. 61
Subject
NCEBP 14: Cardiovascular diseasesAbstract
BACKGROUND: Women with a history of preeclampsia are at increased risk to develop end-stage renal disease. In this longitudinal study, we evaluated renal function in women with a history of severe preeclampsia and parous controls over a period of 14 years. METHODS: Renal function was measured 1 and then 14 years postpartum by para-aminohippurate and inulin clearances in 20 women with a history of severe preeclampsia and 8 parous controls. RESULTS: The difference in glomerular filtration rate 1 year postpartum between women with a history of preeclampsia and parous controls (112 +/- 10 and 125 +/- 8 ml/min/1.73 m(2), p < 0.01) had disappeared 14 years postpartum (104 +/- 10 and 109 +/- 13 ml/min/1.73 m(2), p = 0.37). There was a consistent trend for a lower effective renal plasma flow both 1 and 14 years postpartum (477 +/- 90 and 543 +/- 92, p = 0.09 and 473 +/- 85 and 543 +/- 98 ml/min/1.73 m(2), p = 0.07). CONCLUSIONS: This explorative study suggests no accelerated renal function loss in the first decade after preeclampsia.
This item appears in the following Collection(s)
- Academic publications [238586]
- Electronic publications [122824]
- Faculty of Medical Sciences [90409]
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