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Publication year
2012Source
Aaps Journal, 14, 4, (2012), pp. 883-894ISSN
Publication type
Article / Letter to editor

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Organization
Pharmacology-Toxicology
IMM - Institute for Molecules and Materials
Journal title
Aaps Journal
Volume
vol. 14
Issue
iss. 4
Page start
p. 883
Page end
p. 894
Subject
NCMLS 5: Membrane transport and intracellular motility IGMD 9: Renal disorderAbstract
The ATP-binding cassette transport proteins (ABC transporters) represent important determinants of drug excretion. Protective or excretory tissues where these transporters mediate substrate efflux include the kidney proximal tubule. Regulation of the transport proteins in this tissue requires elaborate signaling pathways, including genetic, epigenetic, nuclear receptor mediated, posttranscriptional gene regulation involving microRNAs, and non-genomic (kinases) pathways triggered by hormones and/or growth factors. This review discusses current knowledge on regulatory pathways for ABC transporters in kidney proximal tubules, with a main focus on P-glycoprotein, multidrug resistance proteins 2 and 4, and breast cancer resistance protein. Insight in these processes is of importance because variations in transporter activity due to certain (disease) conditions could lead to significant changes in drug efficacy or toxicity.
This item appears in the following Collection(s)
- Academic publications [205104]
- Electronic publications [103316]
- Faculty of Medical Sciences [81055]
- Faculty of Science [32347]
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