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Title: Regulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubules
Author(s): Masereeuw, R. ; Russel, F.G.M.
Publication year: 2012
Source: Aaps Journal, vol. 14, iss. 4, (2012), pp. 883-894
ISSN: 1550-7416
DOI: http://dx.doi.org/10.1208/s12248-012-9404-z
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/109335   http://hdl.handle.net/2066/109335

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Subject: NCMLS 5: Membrane transport and intracellular motility IGMD 9: Renal disorder
Organization: Pharmacology-Toxicology
IMM - Institute for Molecules and Materials
Journal title:
Aaps Journal
Volume: vol. 14
Issue: iss. 4
Page start: p. 883
Page end: p. 894
Abstract:
The ATP-binding cassette transport proteins (ABC transporters) represent important determinants of drug excretion. Protective or excretory tissues where these transporters mediate substrate efflux include the kidney proximal tubule. Regulation of the transport proteins in this tissue requires elaborate signaling pathways, including genetic, epigenetic, nuclear receptor mediated, posttranscriptional gene regulation involving microRNAs, and non-genomic (kinases) pathways triggered by hormones and/or growth factors. This review discusses current knowledge on regulatory pathways for ABC transporters in kidney proximal tubules, with a main focus on P-glycoprotein, multidrug resistance proteins 2 and 4, and breast cancer resistance protein. Insight in these processes is of importance because variations in transporter activity due to certain (disease) conditions could lead to significant changes in drug efficacy or toxicity.

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