Recombination gives a new insight in the effective population size and the history of the old world human populations.
Publication year
2012Source
Molecular Biology and Evolution, 29, 1, (2012), pp. 25-30ISSN
Annotation
1 januari 2012
Publication type
Article / Letter to editor

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Organization
Internal Medicine
Dentistry
Journal title
Molecular Biology and Evolution
Volume
vol. 29
Issue
iss. 1
Page start
p. 25
Page end
p. 30
Subject
N4i 1: Pathogenesis and modulation of inflammation NCMLS 1: Infection and autoimmunityAbstract
The information left by recombination in our genomes can be used to make inferences on our recent evolutionary history. Specifically, the number of past recombination events in a population sample is a function of its effective population size (Ne). We have applied a method, Identifying Recombination in Sequences (IRiS), to detect specific past recombination events in 30 Old World populations to infer their Ne. We have found that sub-Saharan African populations have an Ne that is approximately four times greater than those of non-African populations and that outside of Africa, South Asian populations had the largest Ne. We also observe that the patterns of recombinational diversity of these populations correlate with distance out of Africa if that distance is measured along a path crossing South Arabia. No such correlation is found through a Sinai route, suggesting that anatomically modern humans first left Africa through the Bab-el-Mandeb strait rather than through present Egypt.
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- Academic publications [202828]
- Faculty of Medical Sciences [80037]
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