Publication year
2012Source
Archives of Oral Biology, 57, 1, (2012), pp. 102-8ISSN
Annotation
01 januari 2012
Publication type
Article / Letter to editor
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Organization
Dentistry
Tumorimmunology
Journal title
Archives of Oral Biology
Volume
vol. 57
Issue
iss. 1
Page start
p. 102
Page end
p. 8
Subject
NCEBP 2: Evaluation of complex medical interventions; NCMLS 3: Tissue engineering and pathologyAbstract
OBJECTIVE: To investigate the contribution of bone marrow-derived cells to oral mucosa wounds and skin wounds. BACKGROUND: Bone marrow-derived cells are known to contribute to wound healing, and are able to differentiate in many different tissue-specific cell types. As wound healing in oral mucosa generally proceeds faster and with less scarring than in skin, we compared the bone marrow contribution in these two tissues. DESIGN: Bone marrow cells from GFP-transgenic rats were transplanted to irradiated wild-type rats. After recovery, 4-mm wounds were made in the mucoperiosteum or the skin. Two weeks later, wound tissue with adjacent normal tissue was stained for GFP-positive cells, myofibroblasts (a-smooth muscle actin), activated fibroblasts (HSP47), and myeloid cells (CD68). RESULTS: The fraction of GFP-positive cells in unwounded skin (19%) was larger than in unwounded mucoperiosteum (0.7%). Upon wounding, the fraction of GFP-positive cells in mucoperiosteum increased (8.1%), whilst it was unchanged in skin. About 7% of the myofibroblasts in both wounds were GFP-positive, 10% of the activated fibroblasts, and 25% of the myeloid cells. CONCLUSIONS: The results indicate that bone marrow-derived cells are preferentially recruited to wounded oral mucosa but not to wounded skin. This might be related to the larger healing potential of oral mucosa.
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- Academic publications [238441]
- Faculty of Medical Sciences [90373]
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