Photodynamic therapy for skin field cancerization: an international consensus. International Society for Photodynamic Therapy in Dermatology.
Publication year
2012Source
JEADV : Journal of the European Academy of Dermatology and Venereology, 26, 9, (2012), pp. 1063-1066ISSN
Annotation
1 september 2012
Publication type
Article / Letter to editor

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Organization
Dermatology
Journal title
JEADV : Journal of the European Academy of Dermatology and Venereology
Volume
vol. 26
Issue
iss. 9
Page start
p. 1063
Page end
p. 1066
Subject
N4i 4: Auto-immunity, transplantation and immunotherapy ONCOL 5: Aetiology, screening and detection; N4i 4: Auto-immunity, transplantation and immunotherapy ONCOL 5: Aetiology, screening and detectionAbstract
Field cancerization is a term that describes the presence of genetic abnormalities in a tissue chronically exposed to a carcinogen. These abnormalities are responsible for the presence of multilocular clinical and sub-clinical cancerous lesions that explains the increased risks of multiple cancers in this area. With respect to the skin, this term is used to define the presence of multiple non-melanoma skin cancer, its precursors, actinic keratoses and dysplastic keratinocytes in sun exposed areas. The multiplicity of the lesions and the extent of the area influence the treatment decision. Providing at least equivalent efficacy and tolerability, field directed therapies are therefore often more worthwhile than lesion targeted approaches. Photodynamic therapy (PDT) with its selective sensitization and destruction of diseased tissue is one ideal form of therapy for this indication. In the following paper the use of PDT for the treatment of field cancerized skin is reviewed and recommendations are given for its use.
This item appears in the following Collection(s)
- Academic publications [202863]
- Faculty of Medical Sciences [80039]
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