Osteoconduction of impacted porous titanium particles with a calcium-phosphate coating is comparable to osteoconduction of impacted allograft bone particles: in vivo study in a nonloaded goat model.
Publication year
2012Source
Journal of Biomedical Materials Research Part B-Applied Biomaterials, 100, 6, (2012), pp. 1483-9ISSN
Annotation
01 augustus 2012
Publication type
Article / Letter to editor

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Organization
Orthopaedics
Journal title
Journal of Biomedical Materials Research Part B-Applied Biomaterials
Volume
vol. 100
Issue
iss. 6
Page start
p. 1483
Page end
p. 9
Subject
NCEBP 10: Human Movement & Fatigue; NCEBP 10: Human Movement & Fatigue NCMLS 3: Tissue engineering and pathology; NCMLS 3: Tissue engineering and pathologyAbstract
AIMS: Impaction grafting restores bone defects in hip arthroplasty. Defects are reconstructed with bone particles (BoP) as substitute materials with adequate mechanical and biological properties are not yet available. Ceramic particles (CeP) have mechanical drawbacks as opposed to porous titanium particles (TiP). In this in vivo study, bone ingrowth and bone volume in coated and noncoated TiP were compared to porous biphasic calcium-phospate CeP and allograft BoP. Coatings consisted of silicated calcium-phosphate and carbonated apatite. Materials were implanted in goats and impacted in cylindrical defects (diameter 8 mm) in the cancellous bone of the femur. On the basis of fluorochrome labeling and histology, bone ingrowth distance was measured at 4, 8, and 12 weeks. Cross-sectional bone area was measured at 12 weeks. FINDINGS: TiP created a coherent matrix of entangled particles. CeP pulverized and were noncoherent. Bone ingrowth in TiP improved significantly by the coatings to levels comparable to BoP and CeP. Cross-sectional bone area was smaller in CeP and TiP compared to BoP. CONCLUSIONS: The osteoconductive properties of impacted TiP with a calcium-phosphate coating are comparable to impacted allograft bone and impacted biphasic ceramics. A more realistic loaded in vivo study should prove that coated TiP is an attractive alternative to allograft bone.
This item appears in the following Collection(s)
- Academic publications [227425]
- Faculty of Medical Sciences [86157]
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