Publication year
2012Source
Neurobiology of Aging, 33, 2, (2012), pp. 428.e21-31ISSN
Annotation
01 februari 2012
Publication type
Article / Letter to editor

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Organization
Geriatrics
IQ Healthcare
Journal title
Neurobiology of Aging
Volume
vol. 33
Issue
iss. 2
Page start
p. 428.e21
Page end
p. 31
Subject
DCN PAC - Perception action and control NCEBP 11: Alzheimer Centre; NCEBP 11: Alzheimer Centre; NCEBP 14: Cardiovascular diseasesAbstract
In Alzheimer's disease (AD) cerebrovascular function is at risk. Transcranial Doppler, near-infrared spectroscopy, and photoplethysmography are noninvasive methods to continuously measure changes in cerebral blood flow velocity (CBFV), cerebral cortical oxygenated hemoglobin (O(2)Hb), and blood pressure (BP). In 21 patients with mild to moderate AD and 20 age-matched controls, we investigated how oscillations in cerebral blood flow velocity (CBFV) and O(2)Hb are associated with spontaneous and induced oscillations in blood pressure (BP) at the very low (VLF = 0.05 Hz) and low frequencies (LF = 0.1 Hz). We applied spectral and transfer function analysis to quantify dynamic cerebral autoregulation and brain tissue oxygenation. In AD, cerebrovascular resistance was substantially higher (34%, AD vs. control: Delta = 0.69 (0.25) mm Hg/cm/second, p = 0.012) and the transmission of very low frequency (VLF) cerebral blood flow (CBF) oscillations into O(2)Hb differed, with increased phase lag and gain (Delta phase 0.32 [0.15] rad; Delta gain 0.049 [0.014] mumol/cm/second, p both < 0.05). The altered transfer of CBF to cortical oxygenation in AD indicates that properties of the cerebral microvasculature are changed in this disease.
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- Faculty of Medical Sciences [86219]
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