Age-dependent alteration of TGF-beta signalling in osteoarthritis.
SourceCell and Tissue Research, 347, 1, (2012), pp. 257-65
01 januari 2012
Article / Letter to editor
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Cell and Tissue Research
SubjectNCMLS 3: Tissue engineering and pathology N4i 4: Auto-immunity, transplantation and immunotherapy
Osteoarthritis (OA) is a disease of articular cartilage, with aging as the main risk factor. In OA, changes in chondrocytes lead to the autolytic destruction of cartilage. Transforming growth factor-beta has recently been demonstrated to signal not only via activin receptor-like kinase 5 (ALK5)-induced Smad2/3 phosphorylation, but also via ALK1-induced Smad1/5/8 phosphorylation in articular cartilage. In aging cartilage and experimental OA, the ratio ALK1/ALK5 has been found to be increased, and the expression of ALK1 is correlated with matrix metalloproteinase-13 expression. The age-dependent shift towards Smad1/5/8 signalling might trigger the differentiation of articular chondrocytes with an autolytic phenotype.
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