Publication year
2012Source
Human Brain Mapping, 33, 8, (2012), pp. 1763-1779ISSN
Annotation
1 augustus 2012
Publication type
Article / Letter to editor

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Organization
Neurology
Journal title
Human Brain Mapping
Volume
vol. 33
Issue
iss. 8
Page start
p. 1763
Page end
p. 1779
Subject
DCN 2: Functional Neurogenomics NCEBP 10: Human Movement & Fatigue; DCN MP - Plasticity and memory; DCN MP - Plasticity and memory NCEBP 10: Human Movement & FatigueAbstract
Parkinson's disease (PD) is surprisingly heterogeneous: some patients have a prominent resting tremor, while others never develop this symptom. Here we investigate whether the functional organization of the voluntary motor system differs between PD patients with and without resting tremor, and whether these differences relate to the cerebral circuit producing tremor. We compared 18 PD patients with marked tremor, 20 PD patients without tremor, and 19 healthy controls. Subjects performed a controlled motor imagery task during fMRI scanning. We quantified imagery-related cerebral activity by contrasting imagery of biomechanically difficult and easy movements. Tremor-related activity was identified by relating cerebral activity to fluctuations in tremor amplitude, using electromyography during scanning. PD patients with tremor had better behavioral performance than PD patients without tremor. Furthermore, tremulous PD patients showed increased imagery-related activity in somatosensory area 3a, as compared with both healthy controls and to nontremor PD patients. This effect was independent from tremor-related activity, which was localized to the motor cortex, cerebellum, and thalamic ventral intermediate nucleus (VIM). The VIM, with known projections to area 3a, was unique in showing both tremor- and imagery-related responses. We conclude that parkinsonian tremor influences motor imagery by modulating central somatosensory processing through the VIM. This mechanism may explain clinical differences between PD patients with and without tremor. Hum Brain Mapp, 2012. (c) 2011 Wiley Periodicals, Inc.
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- Academic publications [203793]
- Faculty of Medical Sciences [80320]
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